Ultra-low-dose Ct

Ultra-low-dose CT is a computed tomography approach that produces cross-sectional images with substantially less ionizing radiation than standard CT, helping balance diagnostic information with radiation exposure. It works by acquiring x-ray measurements at reduced exposure settings and using optimized image reconstruction, including noise-reduction algorithms, to recover clinically useful detail from noisier data. In medicine, this strategy can support selected examinations such as lung imaging, stone detection, and follow-up studies, particularly when repeated scans or radiation-sensitive patients make dose reduction important. Its effectiveness depends on matching the protocol to the clinical question and preserving adequate image quality for diagnosis.

Ultra-low-dose Ct - Related Videos

Research

JoVE EoE - Neuroimaging

TSPO-PET/CT Imaging to Detect Infarct Formation in a Mouse Model of Ischemic Stroke

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2025

Source: Chaney, A. M., et.al. PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke. J. Vis. Exp. (2018). This video demonstrates a technique for in vivo imaging of neuroinflammation in a mouse model of ischemic stroke using a TSPO-specific radiotracer. Following injection, the radiotracer binds to TSPO, a protein located on the outer mitochondrial membrane and overexpressed in activated immune cells. A PET/CT scanner detects the radiotracer's distribution and...

Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT

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Cited by 37 •

2012

A method of functional imaging of mouse brown adipose tissue (BAT) is described in which cold-stimulated uptake of 18F-Fluorodeoxyglucose (FDG) in BAT is non-invasively assessed with a standardized micro-PET/CT protocol. This method is robust and sensitive to detect differences in BAT activities in mouse models.

Research

JoVE Journal - Medicine
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Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy

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Cited by 49 •

2014

The current priority in breast cancer radiotherapy is to reduce cardiac doses without compromising target tissue coverage. The voluntary breath-hold technique described here is a simple, inexpensive solution to this problem and capable of being instituted widely without the need for specialized equipment.

Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT

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Cited by 15 •

2017

This study describes a protocol that uses 18F-FDG and positron emission tomography/computed tomography (PET/CT) imaging, together with kinetic modelling, to quantify the in vivo, real-time uptake of 18F-FDG into tissues.

FDG Based PET/CT Scan: A Method of Using Radiotracer for Non-invasive Imaging of Tumor Metabolism

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2023

This article describes multimodality imaging of cancerous tissues with PET and CT diagnostic imaging by using a radiotracer 18F-FDG. Cancerous tissue with high glycolytic activity uptakes more 18F-FDG.

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