Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT

The overall goal of this imaging protocol is to quantify the in vivo realtime uptake of glucose from the bloodstream into specific tissues in mice. This method can help answer key questions in the diabetes and metabolism field, such as the impact of any diabetic treatments on glucose uptake and metabolism. The main advantage of this technique is that experiments can be performed longitudinally to assess for example the impact of age or diet on glucose metabolism.

Learning this method provides information about glucose metabolism in sclero muscle. It is also useful in other tissues such as liver and brain and is transferrable to rats. Visual demonstration of this method is critical, as the imaging acquisition and our analysis steps must be completed correctly to ensure accurate results.