Adult Brain
Adult Brain - Related Videos
09:27
Whole Cell Recordings from Brain of Adult Drosophila
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Cited by 40 •
2007
This video demonstrates the procedure for isolating whole brains from adult Drosophila in preparation for recording from single neurons using standard whole cell technology. It includes images of GFP labeled cells and neurons viewed during recording.
09:42
Electrophysiological Recording in the Brain of Intact Adult Zebrafish
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Cited by 14 •
2013
This paper describes how an adult zebrafish can be immobilized, intubated, and used for in vivo electrophysiological experiments to allow recordings and manipulation of neural activity in an intact animal.
11:01
Isolation and Culture of Adult Zebrafish Brain-derived Neurospheres
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Cited by 28 •
2016
Here we provide a reproducible method to examine adult neurogenesis using a neurosphere assay derived from the whole brain or from either the telencephalic, tectal or cerebellar regions of the adult zebrafish brain. Additionally, we describe the procedure to manipulate gene expression in zebrafish neurospheres.
16:47
Preparation of Developing and Adult Drosophila Brains and Retinae for Live Imaging
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Cited by 50 •
2010
This protocol describes three Drosophila preparations: 1) adult brain dissection, 2) adult retina dissection and 3) developing eye disc- brain complexes dissection. Emphasis is laid on special preparation techniques and conditions for live imaging, although all preparations can be used for fixed tissue immunohistochemistry.
03:49
Drosophila Adult Brain Dissection: A Method in Fly Neurobiology
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2023
This video describes how to dissect and isolate the adult Drosophila brain–a procedure necessary for visualizing the organ, which is otherwise obscured by the cuticle, eye, and tracheal tissue. The example protocol shows a detailed demonstration yielding high-quality preparations that can be used for immunostaining and imaging methods in Drosophila neurobiology.
FAQs
Synaptic plasticity allows adult neural circuits to change their functional organization in response to experience, learning, or injury. This adaptability provides a mechanism for modifying circuit activity rather than treating mature connections as fixed. In neuroscience, examining these changes helps relate altered circuit function to learning, recovery, or disease-associated effects.
Communication among adult brain neurons depends on electrical impulses and neurotransmitters acting at synapses. Electrical activity carries signals within neural communication pathways, while neurotransmitters support signaling between cells at synaptic connections. Studying both components helps neuroscientists examine how circuit activity contributes to cognition, memory, movement, behavior, and physiological regulation.
Neural circuits provide a framework for linking cellular communication with broader functions such as cognition, memory, movement, behavior, and physiological regulation. Their organization also helps explain why changes in particular circuit activities can affect different abilities. This circuit-level perspective supports research into how mature brain systems operate and how their function changes with disease or injury.
Researchers study the adult brain to characterize changes associated with aging and neurological disease, focusing on how altered neural organization or circuit activity relates to affected functions. These investigations can connect biological changes with problems involving cognition, motor control, mood, or other essential functions, providing context for evaluating potential interventions.
Circuit-targeting interventions are evaluated when researchers want to determine whether changing neural activity could address altered brain functions. The adult brain provides the relevant context for examining effects on cognition, motor control, mood, or other essential functions. Such studies connect circuit-level mechanisms with treatment development for neurological conditions and related functional impairments.
Studies of the adult brain can clarify how neural organization relates to cognition, memory, movement, behavior, and physiological regulation. They can also characterize changes linked to aging, neurological disease, or injury and assess interventions directed at brain circuits. These outcomes inform the development of treatments for conditions affecting essential brain functions.