Cerebral Thrombus Visualization

Cerebral thrombus visualization is the imaging-based detection and characterization of blood clots within the brain’s vascular system, an essential step in understanding and treating ischemic stroke. Imaging methods reveal where a thrombus forms, how extensively it obstructs blood flow, and how surrounding brain tissue responds by capturing differences in vessel structure, blood movement, or clot-associated signals. In neuroscience research and clinical practice, these observations support stroke diagnosis, assessment of tissue at risk, selection of reperfusion strategies, and evaluation of treatment effectiveness. Experimental visualization also helps clarify thrombus formation and vascular injury, informing the development of targeted therapies and improved monitoring approaches.

Cerebral Thrombus Visualization - Related Videos

Research

JoVE EoE - Neuroimaging

Visualization of a Cerebral Thrombus in a Mouse Using Micro-Computed Tomography Imaging

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2025

Source: Kim, D., et. al. Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli. J. Vis. Exp. (2016)This video demonstrates visualization of cerebral thrombus in mice using micro-computed tomography (micro-CT) imaging. A cerebral thrombus mouse model is injected with fibrin-targeted gold nanoparticles acting as a contrasting agent. The mouse is placed on the bed of a micro-CT machine, and images are acquired from multiple angles.

Visualization of Mouse Cerebral Thrombi Using Near-Infrared Fluorescence Imaging

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2025

Source: Kim, D. E., et al. Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli. J. Vis. Exp. (2016)This video demonstrates near-infrared fluorescent (NIRF) imaging to visualize thrombi in excised brain tissue labeled with a fibrin-specific probe. Near-infrared light excites the probe, causing the thrombus to fluoresce, enabling high-contrast thrombi visualization in the major cerebral artery and small cortical blood vessels.

Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli

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Cited by 8 •

2016

This protocol describes the application of combined near-infrared fluorescent (NIRF) imaging and micro-computed tomography (microCT) for visualizing cerebral thromboemboli. This technique allows the quantification of thrombus burden and evolution. The NIRF imaging technique visualizes fluorescently labeled thrombus in excised brain, while the microCT technique visualizes thrombus inside living animals using gold-nanoparticles.

Intravital Microscopy and Thrombus Induction in the Earlobe of a Hairless Mouse

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Cited by 4 •

2017

The ear model of the hairless SKH1-Hrhr mouse enables intravital fluorescence microscopy of microcirculation and phototoxic thrombus induction without prior surgical preparation in the examined microvascular bed. Therefore, the ear of the hairless mouse is an excellent in vivo model to study the complex interactions during microvascular thrombus formation, thrombus evolution, and thrombolysis.

Intravital Fluorescence Microscopy to Study Microvascular Thrombus Formation

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2025

This video demonstrates the intravital fluorescence microscopy technique to study thrombus formation in a mouse model. The mouse is injected with a fluorophore-labeled polysaccharide to monitor blood circulation. Upon illumination with a high-intensity light, the phototoxic induction of an injury in the microvasculature of the ear leads to the formation of a thrombus, which is confirmed by visualizing the obstruction in the blood flow.

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