Electrode Tissue Interface

The electrode-tissue interface is the boundary where an electronic device connects with living tissue, enabling electrical communication between neural systems and external instruments. At this boundary, ionic currents in tissue interact with electronic currents in the electrode through charge accumulation at the electrical double layer and, in some cases, faradaic reactions; impedance, electrode geometry, and surface materials influence signal quality and safety. In neuroscience, understanding this interface supports reliable neural recording, stimulation, and brain-computer interfaces. Improving biocompatibility, reducing unwanted reactions, and optimizing materials such as conductive polymers or microstructured electrodes can enhance device performance while limiting tissue damage and signal loss.

Electrode Tissue Interface - Related Videos

Research

JoVE Journal - Neuroscience

Fabrication of High Contact-Density, Flat-Interface Nerve Electrodes for Recording and Stimulation Applications

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Cited by 24 •

2016

This article provides a detailed description on the fabrication process of a high contact-density flat interface nerve electrode (FINE). This electrode is optimized for recording and stimulating neural activity selectively within peripheral nerves.

Fabrication of Flat-Interface Nerve Electrodes for Recording Neural Activity

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2025

This video demonstrates the fabrication of a flat nerve-wrapping electrode. It showcases the integration of shielding metal and precise polymer layering for an effective recording surface. The process involves attaching, curing, trimming, and cutting polymer layers for optimal nerve contact and accurate signal recording.

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

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Cited by 44 •

2015

Described herein is a protocol to isolate and analyze the infiltrating leukocytes of tissues at the maternal-fetal interface (uterus, decidua, and placenta) of mice. This protocol maintains the integrity of most cell surface markers and yields enough viable cells for downstream applications including flow cytometry analysis.

Interfacing 3D Engineered Neuronal Cultures to Micro-Electrode Arrays: An Innovative In Vitro Experimental Model

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Cited by 16 •

2015

In this work, a novel experimental model in which 3D neuronal cultures are coupled to planar Micro-Electrode Arrays (MEAs) is presented. 3D networks are built by seeding neurons in a scaffold made up of glass microbeads on which neurons grow and form interconnected 3D structures.

Research

JoVE Journal - Bioengineering
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Bridging the Bio-Electronic Interface with Biofabrication

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Cited by 3 •

2012

This article describes a biofabrication approach: deposition of stimuli-responsive polysaccharides in the presence of biased electrodes to create biocompatible films which can be functionalized with cells or proteins. We demonstrate a bench-top strategy for the generation of the films as well as their basic uses for creating interactive biofunctionalized surfaces for lab-on-a-chip applications.

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