Medial Entorhinal Cortical
Medial Entorhinal Cortical - Related Videos
09:45
Preparation of Parasagittal Slices for the Investigation of Dorsal-ventral Organization of the Rodent Medial Entorhinal Cortex
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Cited by 36 •
2012
We describe procedures for preparation and electrophysiological recording from brain slices that maintain the dorsal-ventral axis of the medial entorhinal cortex (MEC). Because neural encoding of location follows a dorsal-ventral organization within the MEC, these procedures facilitate investigation of cellular mechanisms important for navigation and memory.
11:31
Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex
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Cited by 2 •
2022
Here we present a protocol describing viral transduction of discrete brain regions with optogenetic constructs to permit synapse-specific electrophysiological characterization in acute rodent brain slices.
02:44
Recording of Local Field Potential in Mouse Hippocampal-Entorhinal Cortex Slices
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2025
The video demonstrates a procedure to record the local field potential (LFP) in mouse hippocampal-entorhinal cortex slices. Electrical stimulation is provided at the CA3 stratum radiatum of the hippocampus, which causes changes in the postsynaptic potential at the CA1 stratum pyramidale. The combined change in the membrane potential of CA1 neurons, termed the local field potential, is recorded.
12:30
A Comprehensive Protocol for Manual Segmentation of the Medial Temporal Lobe Structures
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Cited by 33 •
2014
The present work provides a comprehensive set of guidelines for manually tracing the medial temporal lobe (MTL) structures. This protocol can be applied to research involving structural and/or combined structural-functional magnetic resonance imaging (MRI) investigations of the MTL, in both healthy and clinical groups.
09:47
Isolation of Cerebrospinal Fluid from Rodent Embryos for use with Dissected Cerebral Cortical Explants
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Cited by 20 •
2013
The ventricular cerebrospinal fluid (CSF) bathes the neuroepithelial and cerebral cortical progenitor cells during early brain development in the embryo. Here we describe the method developed to isolate ventricular CSF from rodent embryos of different ages in order to investigate its biological function. In addition, we demonstrate our cerebral cortical explant dissection and culture technique that allows for explant growth with minimal volumes of culture medium or CSF.
FAQs
These signals represent complementary features of an animal’s movement and location. Grid-cell patterns contribute spatial organization, head-direction responses indicate orientation, boundary representations relate activity to environmental limits, and speed-related activity reflects movement rate. Their interaction allows the medial entorhinal cortex to form structured spatial maps rather than encoding position through a single signal alone.
Sensory information provides cues about the surrounding environment, while self-motion information tracks movement through that environment. The medial entorhinal cortex transforms both sources into organized spatial representations. Combining them helps maintain a coherent account of location and movement, supporting navigation when experiences must be arranged according to where and how they occur.
Spatial activity in this region organizes experiences according to location, direction, boundaries, and movement. That organization can guide an animal’s navigation while also contributing to the formation and retrieval of memories associated with places or journeys. Its connection between neocortical information and the hippocampus therefore links spatial representation with broader memory-related processing.
The region contains several interacting spatial signals, allowing researchers to examine how neural activity represents location and movement in a structured way. Studying these patterns clarifies how populations of neurons encode features of experience rather than isolated sensations. This makes the medial entorhinal cortex a useful system for investigating spatial coding and hippocampal function.
Research on these circuits can show how sensory and self-motion information is transformed into spatial maps and connected with hippocampal processing. It can also clarify how location, direction, boundaries, and speed are represented together. These outcomes provide insight into the neural organization of navigation, memory formation, memory retrieval, and experience-based spatial structure.
Because its activity contributes to spatial cognition, changes in these circuits may help researchers examine how navigation and memory-related abilities are altered in neurological disease. Investigating its spatial signals and hippocampal connections provides a circuit-level perspective on such changes. This focus connects cellular activity with broader impairments in organizing and retrieving spatial experiences.