Mouse Brain Implantation
Mouse Brain Implantation - Related Videos
05:36
Implantation of an Electrode Assembly in a Mouse Brain for Electrophysiological Recording
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2025
This video demonstrates a technique for implanting an electrode assembly into a mouse brain. The assembly contains bipolar electrodes to record activity from the hippocampus and a reference electrode to obtain baseline activity from the cerebellum. An anesthetized mouse is placed on a stereotaxic frame, and the electrode assembly is implanted in the target brain region. The animal is then allowed to recover before performing electrophysiological recording.
03:58
Implantation of Cranial Imaging Window in Mouse Model: A Surgical Procedure to Implant Glass-based Coverslip for Stable Optical Access to Regions of Murine Brain
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2023
This video presents a surgical procedure to implant cranial window in a mouse model for stable optical access to different regions of the brain.
02:58
Intracranial Orthotopic Model: A Procedure to Implant Cancer Cells in Mouse Brain
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2023
This video demonstrates implantation of tumor cells in the mouse brain by performing intracranial injection.
04:31
Continuous Drug Infusion System in Mouse Model: A Surgical Procedure to Implant Micro-osmotic Pump Infusion System in the Mouse Brain for Continuous Drug Delivery
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2025
In this video, we demonstrate the assembly of a micro-osmotic pump brain infusion system followed by its surgical implantation in the mouse skull. This system enables continuous delivery of potential drugs and facilitates the study of their effects on the brain and brain tissue.
04:48
Intracranial Cannular Implantation in a Mouse to Deliver Therapeutic Agents to Brain Tumors
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2025
This video presents a procedure for intracranial cannula implantation in a brain tumor mouse model, to facilitate the administration of an immunotherapeutic agent. The delivery of glypican-2-specific chimeric antigen receptor T cells in the tumor microenvironment triggers T cell activation, resulting in tumor lysis and tumor regression.
FAQs
Stereotactic guidance links the implant to a defined brain coordinate, allowing researchers to place a device, probe, or biological material at a chosen location. This spatial control matters because the study can relate the implant’s activity, stimulation, or delivery to a particular neural structure, supporting more controlled analysis of neural function.
These implant types provide different experimental access. Electrodes record neural activity, optical fibers can record or modulate it, and cannulas deliver drugs or other substances to a localized site. Selecting among them depends on whether the experiment emphasizes measurement, activity control, or site-specific delivery, allowing implantation to match the intended neuroscience question.
Anesthesia is used during placement, and monitoring continues through recovery and experimentation. This sequence lets researchers distinguish the implantation period from later observations made with the device, probe, or material in place. Attention to these stages is important when interpreting neural, behavioral, disease-related, or treatment-response findings.
Localized cannula delivery links a substance to a defined brain site. Researchers can therefore examine effects of drugs or other substances in relation to the implanted location, rather than treating the brain as a single undifferentiated target. This capability is relevant when studying neural circuits, disease mechanisms, or responses to potential treatments.
Implanted measurements can be paired with behavioral experiments to relate neural activity to observable actions. Electrodes or optical fibers provide access to activity during experimentation, and the resulting observations can help researchers examine circuit function in a living animal. This links neural signals or modulation with behavior rather than considering either in isolation.
Mouse brain implantation supports disease and treatment research by providing an implanted interface or localized delivery route. Researchers can investigate disease mechanisms and examine treatment responses in relation to a defined brain location. These studies help connect an experimental intervention or measurement with changes in neural function or behavior within the living mouse.