Polyglycolic Acid Collagen Tube
Polyglycolic Acid Collagen Tube - Related Videos
07:25
Collagen Hydrogels
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2023
Collagen is another widely used biomaterial that has found popularity in commercial applications, such as photography. Collagen has more recently been used in tissue engineering applications, by creating hydrogels that provide structure to engineered tissue. This video introduces collagen as a biomaterial, demonstrates how it is harvested from porcine skin, and shows how the material is used to create a hydrogel for tissue engineering applications. Finally, several applications of the material...
07:54
In vitro Synthesis of Native, Fibrous Long Spacing and Segmental Long Spacing Collagen
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Cited by 16 •
2012
Simple and reproducible procedures are described for making three structurally distinct collagen assemblies from a common commercially available Type I collagen monomer. Native type, fibrous long spacing or segmental long spacing collagen can be constructed by varying the conditions to which the 300 nm long and 1.4 nm diameter monomer building block is exposed.
05:17
An Improved Method for the Preparation of Type I Collagen From Skin
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Cited by 23 •
2014
Traditional procedures for the isolation of soluble type 1 collagen (COL1) require about 10 days from start to finish because of lengthy buffer incubations and laborious resuspensions of fibrils. Here, we describe a means to purify COL1 from small dermal biopsies in less than 3 hr.
10:56
Tube Thoracostomy
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2023
Source: Rachel Liu, BAO, MBBCh, Emergency Medicine, Yale School of Medicine, New Haven, Connecticut, USA Tube thoracostomy (chest tube placement) is a procedure during which a hollow tube is inserted into the thoracic cavity for drainage of fluid or air. Emergency chest tube insertion is performed for definitive treatment of tension pneumothorax, traumatic hemothorax, large-volume pleural effusions, and empyemas. Irrespective of the cause of air and fluid accumulation in the pleural space, the...
04:30
A Photopolymerizable Hyaluronic Acid-Collagen Model of the Invasive Glioma Microenvironment with Interstitial Flow
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Cited by 2 •
2024
We present a method for replicating the glioma tumor microenvironment at the invasive front that incorporates interstitial fluid flow. This model is a hyaluronan-collagen I hydrogel in a tissue culture insert where a fluid pressure head can be applied. Invasion can be quantified, and cells can be isolated or lysed.
FAQs
The collagen lining provides a permissive scaffold for Schwann cells and regenerating axons. Schwann cells can occupy this internal environment, while axons use the tube as a guided pathway between injured nerve ends. This cellular and structural support is important because successful repair depends not only on bridging the gap, but also on directing biological growth through the reconstruction site.
The polyglycolic acid framework provides initial structural support and then gradually hydrolyzes as healing proceeds. Its eventual absorption allows the implanted framework to diminish over time rather than remain permanently in the repair site. Studying this degradation process helps researchers relate changes in conduit structure to cellular interactions and the progression of axonal growth.
The tube offers an alternative to an autologous nerve graft, which uses nerve tissue from the same individual. Its potential advantage is reducing donor-site injury while simplifying reconstruction. However, its value must be evaluated through its ability to support Schwann cells and axonal regeneration across short gaps, rather than by structural substitution alone.
Research commonly focuses on three connected features: conduit structure, material degradation, and interactions with neural repair cells. Investigators also examine whether the internal environment supports Schwann cell activity and guides regenerating axons. Together, these observations indicate how the biomaterial may influence the continuity and direction of peripheral nerve regeneration.
This approach is suited to studies and reconstructions involving short gaps between injured peripheral nerve ends. The tube is especially relevant when researchers seek a scaffold-based alternative to autologous grafting and want to investigate biodegradable biomaterials. Its use centers on whether the conduit can maintain a supportive pathway long enough for nerve healing and axonal growth.
The central outcomes are restoration of peripheral nerve continuity and the extent to which regenerating axons progress through the repair site. Neuroscience and biomaterials studies may connect these findings with recovery of sensory and motor function. Such evaluations help determine whether the conduit’s material behavior and cellular compatibility translate into meaningful functional repair after nerve injury.