Conjugate Acid-base Pair

A conjugate acid-base pair consists of two chemical species that differ by one proton, with one acting as the acid and the other as its corresponding base. In a Brønsted-Lowry reaction, the acid donates a proton to a base, producing the conjugate base and conjugate acid; proton transfer links each pair, and stronger acids generally form weaker conjugate bases. Identifying these pairs helps chemists predict the direction of acid-base equilibria and compare relative strengths. The concept is central to calculating pH, understanding buffer systems, interpreting aqueous reactions, and selecting reagents for controlling proton transfer in laboratory and industrial chemistry.

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JoVE Core - Chemistry

Relative Strengths of Conjugate Acid-Base Pairs

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2020

Brønsted-Lowry acid-base chemistry is the transfer of protons; thus, logic suggests a relation between the relative strengths of conjugate acid-base pairs. The strength of an acid or base is quantified in its ionization constant, Ka or Kb, which represents the extent of the acid or base ionization reaction. For the conjugate acid-base pair HA / A−, the ionization equilibrium equations and ionization constant expressions are Adding these two chemical equations yields the equation for the...

DNA Base Pairing

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2020

Erwin Chargaff’s rules on DNA equivalence paved the way for the discovery of base pairing in DNA. Chargaff’s rules state that in a double-stranded DNA molecule, the amount of adenine (A) is equal to the amount of thymine (T); the amount of guanine (G) is equal to the amount of cytosine (C); and the sum of purines, A and G, is equal to the sum of pyrimidines, C and T (i.e., A+G = C+T). Later work by Watson and Crick revealed that in double-stranded DNA, A always forms two hydrogen bonds...

Bronsted-Lowry Acids and Bases

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2020

The acid-base reaction class has been studied for quite some time. In 1680, Robert Boyle reported traits of acid solutions that included their ability to dissolve many substances, to change the colors of certain natural dyes, and to lose these traits after coming in contact with alkali (base) solutions. In the eighteenth century, it was recognized that acids have a sour taste, react with limestone to liberate a gaseous substance (now known to be CO2), and interact with alkalis to form neutral...

Ions as Acids and Bases

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2020

Salts with Acidic Ions Salts are ionic compounds composed of cations and anions, either of which may be capable of undergoing an acid or base ionization reaction with water. Aqueous salt solutions, therefore, may be acidic, basic, or neutral, depending on the relative acid-base strengths of the salt’s constituent ions. For example, dissolving the ammonium chloride in water results in its dissociation, as described by the equation: The ammonium ion is the conjugate acid of the base ammonia,...

Acid and Base Concentrations - Concepts

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2020

Acids and Bases An Arrhenius acid produces hydrogen ions when it is dissolved in water: HA + H2O → H+(aq) + A-(aq) Here, HA is the non-dissociated acid, H+ is the hydrogen cation, and A- is the solvated anion — called the conjugate base. An Arrhenius base produces hydroxide ions when dissolved in water: BOH + H2O → B+(aq) + OH-(aq) Here, BOH is the non-dissociated base, OH- is the hydroxide ion, and B+ is the solvated cation — called the conjugate acid. A conjugate base is formed when an acid...

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