Ventricular Extrasystoles

Ventricular extrasystoles are premature heartbeats that originate in the ventricles rather than the sinoatrial node, the heart’s usual pacemaker. They occur when an ectopic ventricular focus depolarizes before the next normal impulse, producing an early, typically wide QRS complex followed by a compensatory pause and a sensation of a skipped or forceful beat. Occasional ventricular extrasystoles may occur in healthy people, whereas frequent, patterned, or symptomatic beats can signal myocardial irritation or underlying structural heart disease. Clinical evaluation uses symptoms, electrocardiography, ambulatory monitoring, and cardiac imaging to assess risk and guide observation, medication, or treatment of the underlying cause.

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Research

JoVE Journal - Medicine

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

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Cited by 4 •

2018

Here, we present a protocol using two centrifugal pumps as a total artificial heart replacement.

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet

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Cited by 22 •

2015

Chronic Thromboembolic Pulmonary Hypertension (CTEPH) and Right Ventricular (RV) dysfunction were induced in piglets by progressive obstruction of the pulmonary arteries. Consequences were remarkably similar to those observed in CTEPH patients. This animal model would be a very useful tool for pathophysiology and therapeutic experiments on CTEPH and RV failure.

Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes

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Cited by 15 •

2013

Kv channel dysfunction is associated with cardiac arrhythmias. In order to study the molecular mechanisms that lead to such arrhythmias we utilize a systematic protocol for isolation of atrial and ventricular cardiomyocytes from Kv channel ancillary subunit knockout mice. Isolated cardiomyocytes can then immediately be used for cellular electrophysiological studies, biochemical or immunofluorescence (IF) assays.

Murine Short Axis Ventricular Heart Slices for Electrophysiological Studies

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Cited by 3 •

2017

Here, we describe the preparation of viable ventricular slices from adult mice and their use for sharp electrode action potential recordings. These multicellular preparations provide a preserved in vivo like tissue structure, which makes them a valuable model for electrophysiological and pharmacological studies in vitro.

Isolation of Embryonic Ventricular Endothelial Cells

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Cited by 4 •

2013

Primary cell culture is a useful technique for analyzing specific populations of cells, particularly from transgenic mouse embryos at specific developmental stages. Herein, embryonic ventricles are dissected and dissociated, and antibody-conjugated beads recognize and separate out the endothelial cells for further analysis.

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