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MAME Models for 4D Live-cell Imaging of Tumor: Microenvironment Interactions that Impact Malignant Progression

Article DOI: 10.3791/3661-v • 08:27 min • February 17th, 2012
February 17th, 2012 •
1, 1, 1, 1,2, 1,2, 1,2
1Department of Pharmacology, Wayne State University, 2Barbara Ann Karmanos Cancer Institute, Wayne State University

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We have developed 3D coculture models for live-cell imaging in real-time of interactions among breast tumor cells and other cells in their microenvironment that impact progression to an invasive phenotype. These models can serve as preclinical screens for drugs to target paracrine-induced proteolytic, chemokine/cytokine and kinase pathways implicated in invasiveness.

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MAME Models 4D Live-cell Imaging Tumor Microenvironment Interactions Malignant Progression Coculture Models Preinvasive Breast Lesions Invasive Phenotype Breast Epithelial Cells Tumor Microenvironment Myoepithelial Cells Fibroblasts Macrophages Blood And Lymphatic Microvascular Endothelial Cells Prostate Cancers 3D Cocultures Live-cell Imaging Functional Proteolysis Assay Breast Ductal Carcinoma In Situ (DCIS) Cells
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