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Journal / Neuroscience / Generering af Topisk Transgene rotter ved
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Generering af Topisk Transgene rotter ved

Article DOI: 10.3791/50146-v • 08:44 min • September 24th, 2013
September 24th, 2013 •
1, 2, 2, 3, 1
1Department of Neuropathology, Medical School Düsseldorf, 2Department of Molecular Genetics, Weizmann Institute for Science, 3Center of Behavioral Neuroscience, University of Düsseldorf

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Gener kan manipuleres under udviklingen af cortex eller hippocampus fra rotte via in utero elektroporation (IUE) ved E16, således at hurtige og målrettede ændringer i neuronal tilslutning til senere undersøgelser af adfærd eller neuropatologi hos voksne dyr. Postnatal in vivo-billeddannelse til styring af IUE succes udføres ved bioluminescens aktivere cotransficeret luciferase.

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Neuroscience Hippocampus Memory skizofreni, Luciferase Forstyrret-i-skizofreni-1 (DISC1)
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