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Developmental Biology

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JoVE Journal Developmental Biology
Menneskelig Pluripotente Stem Cell Based Udviklingstoksicitet Analyser for Kemisk Sikkerhed Screening og Systembiologi data Generation
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Menneskelig Pluripotente Stem Cell Based Udviklingstoksicitet Analyser for Kemisk Sikkerhed Screening og Systembiologi data Generation

Article DOI: 10.3791/52333-v • 17:28 min • June 17th, 2015
June 17th, 2015 •
*1, *2, 1, 1, 1, 3, 3, 4, 2, 1, *2, *1
1Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, 2Department of Biology, University of Konstanz, 3Department of Statistics, Technical University of Dortmund, 4Leibniz Research Centre for Working Environment and Human Factors, Technical University of Dortmund
* These authors contributed equally

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Protokollerne beskriver to in vitro udviklingsmæssige toksicitet testsystemer (UKK og UKN1) baseret på humane embryonale stamceller og transkriptom studier. Testsystemet forudser human udviklingsmæssige fare toksicitet, og kan bidrage til at reducere dyreforsøg, omkostninger og den tid, der kræves til kemisk sikkerhed test.

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Developmental Biology Humane embryonale stamceller udviklingstoksicitet neurotoksicitet neuroektodermal stamceller immunoudfældning differentiering cytotoksicitet embryopathy embryoid krop
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