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JoVE Journal Developmental Biology
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Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Article DOI: 10.3791/52333-v • 17:28 min • June 17th, 2015
June 17th, 2015 •
*1, *2, 1, 1, 1, 3, 3, 4, 2, 1, *2, *1
1Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, 2Department of Biology, University of Konstanz, 3Department of Statistics, Technical University of Dortmund, 4Leibniz Research Centre for Working Environment and Human Factors, Technical University of Dortmund
* These authors contributed equally

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The protocols describe two in vitro developmental toxicity test systems (UKK and UKN1) based on human embryonic stem cells and transcriptome studies. The test systems predict human developmental toxicity hazard, and may contribute to reduce animal studies, costs and the time required for chemical safety testing.

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Human Pluripotent Stem Cells Developmental Toxicity Assays Chemical Safety Screening Systems Biology Data Generation In Vitro Toxicity Testing Potential Drugs Time Course Of Development Regulatory Mechanisms Systems Biology Approaches UKK Test System Human Embryonic Stem Cells (hESC) Embryoid Bodies Three Germ Layers Human-specific Early Embryonic Toxicity/teratogenicity UKN1 Test System Neuroectodermal Progenitor (NEP) Cells Early Neural Development Developmental Neurotoxicity Epigenetic Changes Transcriptome Microarray Studies Toxicity Biomarkers
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