Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model

Hyunki Kim; Sharon Samuel; John W. Totenhagen; Marie Warren; Jeffrey C. Sellers; Donald J. Buchsbaum

doi:10.3791/52641

Journal

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Medicina

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Contraste Dinâmico aprimorada Ressonância Magnética de um Modelo de câncer de pâncreas Orthotopic Rato

Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model

JoVE Journal
Medicina

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JoVE Journal Medicina

Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model

Contraste Dinâmico aprimorada Ressonância Magnética de um Modelo de câncer de pâncreas Orthotopic Rato

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15,106 Views

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06:24 min

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April 18, 2015

DOI:

10.3791/52641-v

DOI:

10.3791/52641-v

•

06:24 min

April 18, 2015

•

15082 Views

Hyunki Kim¹, Sharon Samuel¹, John W. Totenhagen¹, Marie Warren¹, Jeffrey C. Sellers², Donald J. Buchsbaum³

¹Radiology,University of Alabama at Birmingham ²Comprehensive Cancer Center,University of Alabama at Birmingham ³Radiation Oncology,University of Alabama at Birmingham

Summary

The goal of this protocol is to apply dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) for orthotopic pancreatic tumor xenografts in mice. DCE-MRI is a non-invasive method to analyze microvasculature in a target tissue, and useful to assess vascular response in a tumor following a novel therapy.