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Модель сингенной ортотопической остеосаркомы Sprague Dawley Rat с ампутацией для контроля скорости метастазирования
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1Department of Molecular and Comparative Pathobiology,The Johns Hopkins University School of Medicine, 2Sidney Kimmel Comprehensive Cancer Center,Johns Hopkins University, 3Department of Surgery,Johns Hopkins University School of Medicine, 4Department of Coloproctological Surgery,Juntendo University Faculty of Medicine, 5Program for Comparative Medicine, Gene Therapy Program, Perelman School of Medicine,University of Pennsylvania, 6Tuskegee College of Veterinary Medicine, 7Department of Human Pathology,Juntendo University Faculty of Medicine, 8Department of Surgery, Juntendo University Shizuoka Hospital,Juntendo University School of Medicine, 9Department of Urology,The Johns Hopkins School of Medicine, 10Department of Gastroenterology and Minimally Invasive Surgery,Juntendo University Faculty of Medicine
Capítulos
- 00:04Introduction
- 01:19Intratibial Osteosarcoma (OS) Cell Injection
- 02:41Doxorubicin Intravenous Administration
- 03:36Hind Limb Amputation
- 05:08Results: Representative Rat OS Imaging and Analysis
- 06:43Conclusion
Здесь описана сингенная ортотопическая имплантация с последующей процедурой ампутации остеосаркомы со спонтанным легочным метастазированием, которая может быть использована для доклинического исследования биологии метастазирования и разработки новых терапевтических средств.
