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Udtømning af overfladeaktivt stoffer kombineret med skadelig ventilation resulterer i en reproducerbar model af akut respiratorisk nødsyndrom (ARDS)
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Udtømning af overfladeaktivt stoffer kombineret med skadelig ventilation resulterer i en reproducerbar model af akut respiratorisk nødsyndrom (ARDS)

Article DOI: 10.3791/62327-v • 06:22 min • April 7th, 2021
April 7th, 2021 •
*1, *1, 2, 1, 1, 1, 1, 2, 1
1Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt Universität zu Berlin and Berlin Institute of Health Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, 2Chair for Medical Information Technology, RWTH Aachen University
* These authors contributed equally

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En kombination af udvaskning af overfladeaktive stoffer med 0,9 % saltvand (35 mL/kg legemsvægt, 37 °C) og ventilation med lavt tidevandsvolumen med lavt PEEP for at forårsage moderat respiratorinduceret lungeskade (VILI) resulterer i eksperimentel akut respiratorisk nødsyndrom (ARDS). Denne metode giver en model af lungeskader med lav / begrænset recruitability at studere effekten af forskellige ventilationsstrategier i længere perioder.

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Medicin Problem 170 Akut respiratorisk nød syndrom (ARDS) dyremodel to-hit model svin model svin overfladeaktiv udtømning skadelig ventilation respirator induceret lungeskade (VILI)
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