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JoVE Journal Neuroscience
Generatie van organoïden in de menselijke hersenen voor mitochondriale ziektemodellering
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Generatie van organoïden in de menselijke hersenen voor mitochondriale ziektemodellering

Article DOI: 10.3791/62756-v • 08:09 min • June 21st, 2021
June 21st, 2021 •
1, 2, 1,4, 1, 2, 3, 3, 2, 1,5
1Department of General Pediatrics, Neonatology and Pediatric Cardiology, Duesseldorf University Hospital, Medical Faculty, Heinrich Heine University, 2Institute of Neurobiology, Heinrich Heine University, 3Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrueck Center for Molecular Medicine (MDC), 4Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, 5Max Delbrueck Center for Molecular Medicine (MDC)

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We beschrijven een gedetailleerd protocol voor het genereren van door de mens geïnduceerde pluripotente stamcel-afgeleide hersenorganoïden en hun gebruik bij het modelleren van mitochondriale ziekten.

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Neurowetenschappen Nummer 172 hersenorganoïden iPSC's mitochondriale ziekte bio-energetische profilering
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