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En modificeret enkel metode til induktion af myokardieinfarkt hos mus
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En modificeret enkel metode til induktion af myokardieinfarkt hos mus

Article DOI: 10.3791/63042-v • 04:29 min • December 3rd, 2021
December 3rd, 2021 •
*1,2, *1,2, *2, 1, 1, 1,2
1Department of Cardiology, The First Affiliated Hospital of Bengbu Medical College, 2Department of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
* These authors contributed equally

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Under tilstrækkelig anæstesi blev musehjertet eksternaliseret gennem det interkostale rum, og myokardieinfarkt blev succesfuldt induceret ved at ligere den venstre forreste nedadgående arterie (LAD) ved hjælp af materialer, der var let tilgængelige i de fleste laboratorier.

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Modificeret enkel metode Induktion af myokardieinfarkt MI-modeller Post-MI-remodellering Ny terapi Isoproterenolbehandling Kryoskade Koronararterieligering Iskæmisk respons Kronisk ombygning Tekniske udfordringer Let tilgængelige materialer Musens brysthud Interkostal plads Pectoralis major Pectoralis minor Venstre forreste nedadgående gren (LAD) 6-0 Sutur 2,3,5-Triphenyltetrazoliumchlorid (TTC) Arstørrelsesændringer Overlevelsesanalyseresultater Hjertebrud Ekkokardiografisk vurdering
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