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Multiple Intravenous Bolus Dosing and Invasive Hemodynamic Assessment in a Hypoxia-Induced Mouse Pulmonary Artery Hypertension Model
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Multiple Intravenous Bolus Dosing and Invasive Hemodynamic Assessment in a Hypoxia-Induced Mouse Pulmonary Artery Hypertension Model

Article DOI: 10.3791/63839-v • 08:51 min • November 11th, 2022
November 11th, 2022 •
1, 2, 3, 3, 4,5, 4
1Department of Surgery, Yale University School of Medicine, 2Department of Vascular Surgery, The First Hospital of China Medical University, Key Laboratory of Pathogenesis, Prevention, and Therapeutics of Aortic Aneurysm, 3VasoRx Inc., 4Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, 5Department of Cell Biology, Yale University School of Medicine

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This protocol provides a step-by-step procedure for executing multiple intravenous bolus dose administration and invasive hemodynamic monitoring in mice. Investigators can use this protocol for future therapeutic compound screening for pulmonary artery hypertension.

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Intravenous Bolus Dosing Invasive Hemodynamic Assessment Hypoxia-induced Mouse Pulmonary Artery Hypertension Model Pulmonary Arterial Hypertension PAH Research Experimental Therapies Mouse Jugular Vein Arterial Catheterization Right Ventricle Catheterization PAH Model
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