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Verabreichung kardioaktiver Therapeutika in einem Schweine-Myokardinfarkt-Modell
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Verabreichung kardioaktiver Therapeutika in einem Schweine-Myokardinfarkt-Modell

Article DOI: 10.3791/64177-v • 07:20 min • February 10th, 2023
February 10th, 2023 •
*1,2, *1, 1,2, 1, 2, 2, 2, 2, 3, 4, 2, 2, 1,2, 1,2
1Centre for Heart Research, The Westmead Institute for Medical Research, The University of Sydney, 2Department of Cardiology, Westmead Hospital, 3Sydney Imaging, Core Research Facility, The University of Sydney, 4Department of Cardiothoracic Surgery, Liverpool Hospital
* These authors contributed equally

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Das vorliegende Protokoll beschreibt drei Methoden zur Verabreichung kardioaktiver Therapeutika in einem Schweinemodell. Weibliche Landrassenschweine erhielten die Behandlung entweder: (1) Thorakotomie und transepikardiale Injektion, (2) kathetergestützte transendokardiale Injektion oder (3) intravenöse Infusion über die osmotische Minipumpe der Jugularvene.

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Kardioaktive Therapeutika Myokardinfarkt Medikamentenverabreichung Schweinemodell Großtiermodelle Therapeutische Verabreichung Schweine Präklinische Bewertung Neuartige Wirkstoffe Thorakotomie Transepikardiale Injektion Katheterbasierte Transendokardiale Injektion Intravenöse Infusion Osmotische Minipumpe der Halsvene Reproduzierbare Verfahren Zuverlässige Medikamentenabgabe Translationale Wissenschaft
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