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Bioengineering

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JoVE Journal Bioengineering
Kardiotoxicitetsscreening med hög kapacitet med mogna humaninducerade pluripotenta stamcellshärledda kardiomyocytmonolager
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Kardiotoxicitetsscreening med hög kapacitet med mogna humaninducerade pluripotenta stamcellshärledda kardiomyocytmonolager

Article DOI: 10.3791/64364-v • 14:03 min • March 24th, 2023
March 24th, 2023 •
1, 2, 3, 1, 1
1Frankel Cardiovascular Regeneration Core Laboratory, Cardiovascular Medicine-Internal Medicine, University of Michigan, Ann Arbor, 2CAIRN Research, 3StemBioSys, Inc.

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Humant inducerade pluripotenta stamcellshärledda kardiomyocyter (hiPSC-CMs) erbjuder ett alternativ till att använda djur för preklinisk kardiotoxicitetsscreening. En begränsning för den utbredda användningen av hiPSC-CMs vid preklinisk toxicitetsscreening är cellernas omogna, fosterliknande fenotyp. Här presenteras protokoll för robust och snabb mognad av hiPSC-CM.

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Denna månad i JoVE nummer 193
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