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Translationelle ortopiske modeller af glioblastom multiforme

Article DOI: 10.3791/64482-v • 07:37 min • February 17th, 2023
February 17th, 2023 •
1, 1, 1
1Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, National Cancer Institute

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Her beskriver vi en præklinisk ortopisk musemodel for GBM, etableret ved intrakraniel injektion af celler afledt af genetisk manipulerede musemodeltumorer. Denne model viser sygdomskendetegnene for human GBM. Til translationelle undersøgelser spores musehjernetumoren ved in vivo MR og histopatologi.

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Denne måned i JoVE nummer 192
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