Visual Perturbations
Visual Perturbations - Related Videos
07:07
Optogenetic Perturbation of Neural Activity with Laser Illumination in Semi-intact Drosophila Larvae in Motion
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Cited by 13 •
2013
Here we describe a protocol for optogenetic manipulation of motoneuronal activity while monitoring changes in motor output (muscle contraction) in semi-intact Drosophila larvae using lasers within a conventional confocal microscope. This technique enables researchers to achieve local perturbation of neural activity in a few neuromeres to elucidate the dynamics of motor circuits.
10:37
Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
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Cited by 6 •
2016
We describe the use of a multiplexed high-throughput gene expression platform that quantitates gene expression by barcoding and counting molecules in biological substrates without the need for amplification. We used the platform to quantitate microRNA (miRNA) expression in whole blood in subjects with and without irritable bowel syndrome.
07:49
Application of Consistent Massage-Like Perturbations on Mouse Calves and Monitoring the Resulting Intramuscular Pressure Changes
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Cited by 5 •
2019
Here we describe the protocols for applying defined mechanical loads to mouse calves and for monitoring the concomitant intramuscular pressure changes. The experimental systems that we have developed can be useful for investigating the mechanism behind the beneficial effects of physical exercise and massage.
09:20
Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption
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Cited by 6 •
2019
Here, we present a mechanics-based protocol to disrupt the gap junction connexin 43 and measure the subsequent impact this has on endothelial biomechanics via observation of tractions and intercellular stresses.
00:07
Accurate Determination of the Equilibrium Surface Tension Values with Area Perturbation Tests
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Cited by 1 •
2019
Two protocols for determining the equilibrium surface tension (EST) values using the emerging bubble method (EBM) and the spinning bubble method (SBM) are presented for a surfactant-containing aqueous phase against air.
FAQs
Researchers change one selected feature of a visual stimulus or viewing condition while keeping other relevant features constant. This controlled comparison links any resulting change to the altered cue rather than to multiple simultaneous differences. Measuring behavioral, neural, or device responses then provides a way to quantify how strongly that cue contributes to visual processing or system performance.
Relevant variables include contrast, color, spatial structure, motion, and timing. Each feature can probe a different aspect of how visual information is represented or used by a biological or engineered system. Selecting among these variables allows experiments to examine responses to altered appearance, organization, movement, or temporal presentation without changing every property of the stimulus at once.
The same altered visual condition can reveal whether a biological system, a device, or a computational model responds consistently to a particular cue. Because the perturbation is controlled, differences in behavioral, neural, or device responses can be interpreted in relation to the selected visual feature. This supports more informative comparisons than testing systems only under unchanged viewing conditions.
A model can be evaluated with visual inputs that differ in contrast, color, spatial structure, motion, or timing from otherwise comparable inputs. Its responses under these altered conditions indicate whether its performance depends strongly on a particular cue or remains stable when viewing conditions change. Such testing helps guide models intended to remain reliable across varied visual information.
First, select the visual cue or viewing condition to examine and specify the response of interest. Next, alter that feature while holding other relevant variables constant. The biological or engineered system is then exposed to the controlled stimulus, and its behavioral, neural, or device response is quantified. Comparing outcomes across conditions reveals the contribution of the selected change.
Bioengineers apply these controlled tests to study sensory processing, evaluate vision prostheses, and develop assistive technologies. Perturbations can show how altered visual information affects system responses and whether an engineered solution handles changes in the input. The resulting measurements support validation by connecting a device or intervention's performance to specific visual cues and viewing conditions.