Non-destructive Technique
Non-destructive Technique - Related Videos
08:24
Introduction to the Ultrasound Targeted Microbubble Destruction Technique
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Cited by 19 •
2011
Ultrasound Targeted Microbubble Destruction (UTMD) can be used to direct site-specific delivery of bioactive molecules, including therapeutic genes, to target organs accessible to ultrasound, such as the heart and liver1-6.
09:24
Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products
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Cited by 2 •
2017
A simple and non-destructive technique that measures the average content of drug substances in formulated drug products containing fluorine using low-field fluorine-19 (19F) time-domain (TD) nuclear magnetic resonance (NMR) is presented here. The technique can be applied to the development and manufacturing of drugs in the pharmaceutical industry.
01:12
Non-destructive Tests for Concrete Strength
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2024
The rebound hammer test, also known as the Schmidt hammer test, is a non-destructive technique for evaluating the hardness of concrete and, indirectly, the strength of concrete. It operates on the principle that the rebound of a spring-driven mass from a concrete surface correlates to the surface's hardness. The device comprises a mass within a tubular housing, a spring mechanism, and a plunger that strikes the concrete. Upon release, the energy imparted to the mass by the spring causes it to...
11:34
Subsurface Defect Localization by Structured Heating Using Laser Projected Photothermal Thermography
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Cited by 7 •
2017
This method aims at locating vertical subsurface defects. Here, we couple a laser with a spatial light modulator and trigger its video input to heat a sample surface deterministically with two anti-phased modulated lines while acquiring highly resolved thermal images. The defect position is retrieved from evaluating thermal wave interference minima.
10:13
Non-Destructive Evaluation of Regional Cell Density Within Tumor Aggregates Following Drug Treatment
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Cited by 8 •
2022
The present protocol develops an image-based technique for rapid, non-destructive, and label-free regional cell density and viability measurement within 3D tumor aggregates. Findings revealed a cell-density gradient, with higher cell densities in core regions than outer layers in developing aggregates and predominantly peripheral cell death in HER2+ aggregates treated with Trastuzumab.
FAQs
Analytical information comes from signals generated when a sample interacts with a probe such as light, radiation, or a magnetic field. The measured signal can be interpreted to evaluate composition, identify compounds, monitor a reaction, or examine structural and surface features. Because the sample remains available afterward, the same material can support repeated measurements or later analyses.
Preservation prevents the measurement itself from changing the evidence being studied. This matters when a sample is limited, valuable, or irreplaceable, because cutting, dissolving, or consuming it could prevent confirmation by another method. Maintaining the original material also allows researchers to repeat measurements and compare observations over time without introducing changes caused by sample preparation.
The probe is selected according to the interaction that can produce useful information about the material. Light, radiation, magnetic fields, and other probes generate different measurable signals, which can support different goals such as compound identification, composition assessment, or examination of structural and surface features. This flexibility lets chemists match the measurement approach to the property under investigation.
Spectroscopy and imaging emphasize complementary information. Spectroscopic measurements use signals associated with a sample to help identify compounds or assess composition, whereas imaging reveals features across a surface or structure. Together, these approaches can provide both chemical and spatial perspectives while keeping the material intact, which is useful when composition and physical features must be evaluated together.
A typical workflow begins by selecting an intact sample and an appropriate probe, then measuring the signal produced by the sample’s interaction with that probe. The resulting data are examined for information about compounds, composition, reactions, structure, or surfaces. If the sample remains usable, researchers can repeat the measurement, compare results, or preserve it for subsequent investigation.
They are especially valuable when testing could otherwise damage the material or when repeated assessment is needed. Applications include quality control, conservation, process monitoring, and research involving limited or irreplaceable samples. In chemistry, the measurements can follow reactions, assess composition, identify compounds, or examine structural and surface characteristics while preserving material for continued use.