Pulsus Paradoxus

Pulsus paradoxus is an exaggerated decrease in systolic blood pressure during inspiration, typically greater than 10 mmHg, and is an important clinical sign of altered cardiopulmonary function. During inspiration, increased venous return can expand the right ventricle, shift the interventricular septum toward the left ventricle, and reduce left ventricular filling and stroke volume, producing a larger-than-normal pressure drop. Clinicians assess it with a blood pressure cuff or arterial waveform, particularly when evaluating cardiac tamponade, severe asthma, chronic obstructive pulmonary disease, or other conditions that impair ventricular interaction. Recognizing this finding can support urgent diagnosis, guide further testing, and help monitor treatment.

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JoVE Science Education - Clinical Skills

Pericardiocentesis

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2023

Source: Rachel Liu, BAO, MBBCh, Emergency Medicine, Yale School of Medicine, New Haven, Connecticut, USA The heart lies within the pericardium, a relatively inelastic fibrous sac. The pericardium has some compliance to stretch when fluid is slowly introduced into the pericardial space. However, rapid accumulation overwhelms pericardial ability to accommodate extra fluid. Once a critical volume is reached, intrapericardial pressure increases dramatically, compressing the right ventricle and...

Research

JoVE Journal - Medicine
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Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats

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2016

Early stage hemodynamic dysfunction is critical to the development of kidney disease. Yet, detection methodologies are limited. Recent advances in sonography provide a noninvasive, accurate option for early detection of kidney injury. This study outlines a step-by-step, sonographic methodology for detecting kidney dysfunction using a drug-induced nephrotoxicity rat model.

Preparation of Intact Bovine Tail Intervertebral Discs for Organ Culture

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2012

This protocol illustrates a harvesting technique for coccygeal bovine intervertebral discs for organ culture for in vitro organ culture.

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