Simple Organism Models
Simple Organism Models - Related Videos
01:35
Organ-on-Chip Models
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2026
Introduction to Organ-on-Chip Models Organ-on-chip models are advanced microphysiological systems that recreate key structural and functional features of human organs in a controlled laboratory setting. These devices integrate living human cells within microfluidic channels, allowing researchers to simulate tissue–tissue interfaces, fluid flow, and mechanical forces that are essential for normal organ function. Unlike traditional cell cultures, which often lack these dynamic physiological cues,...
08:52
High-resolution Episcopic Microscopy (HREM) - Simple and Robust Protocols for Processing and Visualizing Organic Materials
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Cited by 38 •
2017
We provide simple and robust protocols for processing biopsy material of various species, embryos of biomedical model organisms and samples of other organic tissues in order to permit digital volume data generation with the high-resolution episcopic microscopy method.
09:36
Genetic Engineering of Model Organisms
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2023
Transgenesis, or the use of genetic engineering to alter gene expression, is widely used in the field of developmental biology. Scientists use a number of approaches to alter the function of genes to understand their roles in developmental processes. This includes replacement of a gene with a nonfunctional copy, or adding a visualizable tag to a gene that allows the resultant fusion protein to be tracked throughout development. In this video, the viewers will learn about the principles behind...
06:21
A Simple and Scalable Fabrication Method for Organic Electronic Devices on Textiles
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Cited by 1 •
2017
In this paper, we present a protocol to selectively deposit organic materials on textiles, which allows for the direct integration of organic electronic devices with wearables. The fabricated devices can be fully integrated in textiles, respecting their mechanical appearance and enabling sensing capabilities.
01:36
Worms as an Alternative Model Organism
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2026
All animal procedures described here must be conducted in accordance with institutional animal ethics guidelines and approved by IACUC. All procedures must follow the principles of the 3Rs—Replacement, Reduction, and Refinement—and must be performed by trained personnel. Introduction to C. elegans The nematode (roundworm) Caenorhabditis elegans, commonly known as C. elegans, is a widely used non-vertebrate animal model for studying fundamental biological processes. Because many cellular and...
FAQs
Their main mechanistic value is that genetic changes can be related to visible changes in cell division, differentiation, migration, or morphogenesis. Researchers therefore use phenotype analysis to test whether altered gene activity is associated with a particular developmental process, rather than examining molecular regulation and tissue organization separately.
The choice depends on which experimental advantages best fit the question: a relatively simple body plan, short generation time, accessible embryos, or a well-characterized genome. These features make some systems especially practical for tracing developmental events or testing genetic mechanisms, while keeping experiments experimentally tractable.
When a pathway or regulatory mechanism is shared across established models, experiments can expose a fundamental developmental principle in a tractable system. Researchers can then formulate testable connections between gene activity and tissue organization, using the model as a way to investigate mechanisms relevant to more complex organisms.
A study may begin with genetic manipulation, continue with microscopy of embryos or tissues, and end with phenotype analysis. This sequence lets investigators compare altered and observed states, linking a manipulated gene or regulatory process to changes in division, differentiation, migration, or morphogenesis.
Their findings can reveal developmental mechanisms that also matter when development is disrupted. Because experiments generate testable principles rather than only descriptive observations, the resulting evidence can support investigation of disease mechanisms and potential therapeutic strategies, while also providing a basis for comparing developmental regulation across organisms.
Comparing developmental mechanisms across these systems can show which signaling pathways and regulatory mechanisms are conserved. Those shared features provide evidence for broadly maintained biological principles, making the models useful for connecting developmental biology with questions about how developmental programs are conserved through evolution.