Thin Disc
Thin Disc - Related Videos
14:33
Generation, Purification, and Characterization of Cell-invasive DISC1 Protein Species
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Cited by 13 •
2012
The generation, purification and cell invasion of intracellular, cytoplasmic full length DISC1 protein aggresomes from cell cultures and of a labeled, multimeric recombinant DISC1 protein fragment in E. coli are described. Cell invasiveness is shown for recipient cells in cell culture and for neurons in vivo after stereotactical brain inoculation.
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An Introduction to Modeling Behavioral Disorders and Stress
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2023
Recently, it has been discovered that behavioral conditions such as, depression, anxiety and stress-response have a neurological basis. Understanding the biological underpinnings of these conditions may help scientists in developing more effective therapies to treat these disorders. Typically, rodent models are used in this field and behavioral scientists create these models using interventions like drug administration or surgery. It is important to understand how to create and evaluate rodent...
FAQs
Radial stress acts along lines extending from the center toward the rim, while circumferential stress acts around the disc. Applied loads and rotation generate these stress components together, and their distribution depends on the disc’s geometry, material properties, and support conditions. Evaluating both is essential for assessing strength, deformation, and possible failure in rotating or pressure-loaded components.
Because the thickness is small compared with the diameter, engineers can often simplify the analysis by treating the dominant stresses as acting within the disc’s plane. This reduces the complexity of predicting deformation and strength while retaining the important radial and circumferential effects. The approximation supports efficient evaluation of lightweight structures and rotating machinery.
Deformation depends on more than the applied load. Material properties govern how readily the disc responds, while geometry affects the structural distribution of stress and stiffness. Support conditions also change the response by restricting or permitting movement. Rotation introduces another important loading condition, so engineers must consider material, dimensions, supports, and loading together when predicting performance.
An analysis begins by specifying the disc’s material properties, geometry, support conditions, and loading. The engineer then evaluates the resulting radial and circumferential stresses and the associated deformation, using the plane-stress approximation when appropriate. These results can be used to judge strength, stiffness, vibration behavior, and potential failure, rather than relying on geometry alone.
Engineers apply this analysis to components such as flywheels, turbine rotors, and brake discs, where rotation can produce significant structural stresses and deformation. The calculations help determine whether the component can maintain adequate strength and stiffness during operation. They also support designs that use material efficiently while targeting safer and higher-performance mechanical systems.
For pressure-loaded circular plates, the model relates loading and support conditions to radial and circumferential stresses and resulting deformation. In lightweight structures, the same approach helps engineers examine how reduced material affects stiffness and strength. The resulting predictions can guide safer designs, efficient material use, and evaluation of failure risks in circular components.