Bronchial Absorption
Bronchial Absorption - Related Videos
14:39
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Cited by 4 •
2010
Bronchial thermoplasty is a non-drug procedure for severe persistent asthma that delivers thermal energy to the airway wall in a precisely controlled manner to reduce excessive airway smooth muscle. Reducing airway smooth muscle decreases the ability of the airways to constrict, thereby reducing the frequency of asthma attacks.
14:32
Primary Human Bronchial Epithelial Cells Grown from Explants
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Cited by 19 •
2010
Here we describe a detailed method for growing primary human bronchial epithelial cells from explants of human bronchial airway tissue including differentiated growth on an air-liquid interface. This method provides an abundant source of primary cells for investigating the role of the airway epithelium in human lung health and disease.
11:54
Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
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Cited by 51 •
2018
This manuscript describes the use of nasal and bronchial absorption techniques, specifically using synthetic absorptive matrices (SAM) to sample the mucosal lining fluid (MLF) of the upper and lower airway. These methods provide better standardization and tolerability than existing respiratory sampling techniques.
01:23
The Bronchial Tree
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2025
The human bronchi and bronchial tree play a crucial role in the respiratory system, facilitating the exchange of oxygen and carbon dioxide. Let's delve into the intricate structure and functions of these respiratory components. The trachea, commonly known as the windpipe, is a tube that connects the larynx (voice box) to the bronchi. At a point called the carina, it bifurcates into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left primary...
09:12
Optimal Lentivirus Production and Cell Culture Conditions Necessary to Successfully Transduce Primary Human Bronchial Epithelial Cells
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Cited by 13 •
2016
Primary human bronchial epithelial cells are difficult to transduce. This protocol describes the production of lentiviruses and their concentration as well as the optimal culture conditions necessary to achieve highly efficient transductions in these cells throughout differentiation to a pseudostratified epithelium.
FAQs
Particle characteristics help determine where material deposits within the bronchial tree and how it interacts with airway lining fluid. These factors can therefore affect the amount available for uptake before mucociliary clearance removes it. In medicine, considering particle behavior is important when optimizing inhaled formulations intended to produce a consistent local pulmonary effect or contribute to systemic exposure.
Mucociliary clearance can remove deposited material from the airways before it has sufficient opportunity to dissolve and cross the respiratory epithelium. Its influence means that deposition alone does not establish how much substance will be absorbed. Evaluating this process helps explain differences between the amount inhaled and the amount ultimately available to surrounding tissues or the bloodstream.
The condition of the airways can influence how an inhaled substance behaves after deposition and how readily it becomes available for uptake. This variable is especially relevant when comparing patients or interpreting drug responses in respiratory disease. Including airway condition in an assessment can help distinguish differences related to the biological environment from differences caused by the inhaled formulation itself.
A useful evaluation follows the substance from deposition in the bronchial tree to dissolution in airway lining fluid, passage across the respiratory epithelium, and possible appearance in surrounding tissues or the bloodstream. Mucociliary clearance, particle characteristics, and airway condition are considered alongside these stages. This workflow connects the inhaled dose with the local or systemic outcome being studied.
During inhaled medicine development, bronchial absorption helps investigators consider whether a compound should remain primarily in the lungs or become available for systemic circulation. The same process supports formulation optimization by linking deposition and uptake with intended therapeutic action. These considerations are relevant to treatments for respiratory diseases and to efforts to understand why drug responses may vary.
Bronchial absorption provides a framework for assessing what may happen after inhaled environmental or aerosolized material deposits in the airways. Examining dissolution, epithelial passage, clearance, particle characteristics, and airway condition helps relate exposure to potential uptake. This perspective supports aerosol safety assessment while also connecting inhalation conditions with possible tissue or bloodstream exposure.