Cold-induced Vasodilation

Cold-induced vasodilation is a physiological response in which blood flow intermittently increases in skin exposed to cold, particularly in the fingers, toes, ears, and nose. Initially, sympathetic nerve activity constricts cutaneous blood vessels to limit heat loss, but periodic reductions in vasoconstriction and local vascular responses can produce transient vessel dilation despite the low temperature. This response may help moderate tissue cooling and reduce the risk of cold injury, although it does not prevent frostbite under severe or prolonged exposure. In medicine, cold-induced vasodilation is assessed in studies of thermoregulation, peripheral circulation, frostbite susceptibility, and conditions such as Raynaud phenomenon.

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Research

JoVE Journal - Medicine
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Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

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Cited by 165 •

2010

A noninvasive procedure to assess endothelial function is demonstrated using the Endo-PAT 2000.

Research

JoVE Journal - Immunology and Infection

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

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Cited by 1 •

2017

We describe the isolation of cardiac extracellular matrix from C57Bl/6J control mice, tight-skin mice, and tight-skin mice treated with the IRF5 inhibitory peptide. We also describe the vasodilation studies on the isolated vessels from C57Bl/6J, tight-skin mice and tight-skin mice treated with the IRF5 inhibitory peptide.

Education

JoVE Core - Pharmacology

Antihypertensive Drugs: Vasodilators

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2024

Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...

Working with Hot and Cold Sources

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2023

Source: Robert M. Rioux & Suprita Jharimune, Pennsylvania State University, University Park, PA Working with extreme temperatures, both high and low, is an integral part of many laboratory operations. For many, mentioning a laboratory instantly evokes the mental picture of a Bunsen burner. Bunsen burners and hot plates are used extensively in small and large operations in research laboratories and industries, thus making it necessary for all users to be aware of their safe handling...

Liver Cold Storage and Transplantation in the Cold-Adaptive Daurian Ground Squirrels

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2025

Here, we present a protocol to establish a long-term liver cold storage and transplantation model in Daurian ground squirrel (DGS), which has been technically challenging in standard rodent models.

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