Heparin Sodium Injection

Heparin sodium injection is a parenteral anticoagulant used to prevent and treat harmful blood clot formation in clinical medicine. It works by binding to and accelerating antithrombin activity, thereby inhibiting thrombin and clotting factor Xa and reducing fibrin development; it prevents clot growth but does not dissolve established clots. Clinicians use it for venous thromboembolism management and prophylaxis, during cardiovascular procedures, and in settings such as hemodialysis where clot prevention is essential. Because its effect can increase bleeding risk, treatment commonly requires dose adjustment and laboratory monitoring.

Heparin Sodium Injection - Related Videos

Research

JoVE Journal - Medicine
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Retinal Detachment Model in Rodents by Subretinal Injection of Sodium Hyaluronate

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Cited by 44 •

2013

Creating experimental retinal detachments with a reproducible and sustained height of detachment, and without subretinal hemorrhage, is important for studying the pathophysiology of photoreceptor cell loss in retinal disease and evaluating potential therapeutic interventions. Here, we report such a method in detail.

Research

JoVE EoE - Viral Growth and Techniques

Purification of Viral Integrase Using Heparin Affinity Chromatography

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2026

Source: Lopez Jr., M. et al. Detection and Removal of Nuclease Contamination During Purification of Recombinant Prototype Foamy Virus Integrase. J. Vis. Exp. (2017)This video demonstrates the procedure for purifying viral integrase from bacterial nuclease contamination using heparin Sepharose column chromatography followed by SDS-PAGE analysis to confirm protein purity.

Using a GFP-tagged TMEM184A Construct for Confirmation of Heparin Receptor Identity

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Cited by 2 •

2017

A construct encoding TMEM184A with a GFP tag at the carboxy-terminus designed for eukaryotic expression, was employed in assays designed to confirm the identification of TMEM184A as a heparin receptor in vascular cells.

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery

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Cited by 2 •

2016

Self-assembled polyelectrolyte complexes (PEC) fabricated from heparin and protamine were deposited on alginate beads to entrap and regulate the release of osteogenic growth factors. This delivery strategy enables a 20-fold reduction of BMP-2 dose in spinal fusion applications. This article illustrates the benefits and fabrication of PECs.

Tuina Intervention in Sodium Monoiodoacetate Injection-Induced Rat Model of Knee Osteoarthritis

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Cited by 1 •

2024

This protocol describes the methods of Tuina intervention in sodium monoiodoacetate injection-induced rat model of knee osteoarthritis (KOA), which provides a reference for the application of Tuina in KOA animal models. This protocol also studies the effective mechanism of Tuina for KOA, and the results will help promote its application.

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