Toggle Clamp Sealing
Toggle Clamp Sealing - Related Videos
09:43
Patch Clamp Electrophysiology
0 Views •
2023
Neuron cell membranes are populated with ion channels that control the movement of charge into and out of the cell, thereby regulating neuron firing. One extremely useful technique for investigating the biophysical properties of these channels is called patch clamp recording. In this method, neuroscientists place a polished glass micropipette against a cell and apply suction to form a high resistance seal. This process isolates a small “patch” of membrane that contains one or more ion channels.
04:41
Optimized Sealing Process and Real-Time Monitoring of Glass-to-Metal Seal Structures
0 Views •
Cited by 7 •
2019
Key procedures to optimize the sealing process and achieve real-time monitoring of the metal-to-glass seal (MTGS) structure are described in detail. The embedded fiber Bragg grating (FBG) sensor is designed to achieve online monitoring of temperature and high-level residual stress in the MTGS with simultaneous environmental pressure monitoring.
13:07
One-channel Cell-attached Patch-clamp Recording
0 Views •
Cited by 17 •
2014
Described here is a procedure for obtaining long stretches of current recording from one ion channel with the cell-attached patch-clamp technique. This method allows for observing, in real time, the pattern of open-close channel conformations that underlie the biological signal. These data inform about channel properties in undisturbed biological membranes.
07:51
The C-seal: A Biofragmentable Drain Protecting the Stapled Colorectal Anastomosis from Leakage
0 Views •
Cited by 8 •
2010
The C-seal is a biofragmentable drain protecting the stapled colorectal anastomosis. In this video, details of the manufacturing, deployment and use are shown.
11:01
A Computer-assisted Multi-electrode Patch-clamp System
0 Views •
Cited by 50 •
2013
Multi-electrode patch-clamp recordings constitute a complex task. Here we show how, by automating of many of the experimental steps, it is possible to accelerate the process leading to qualitative improvement in performance and number of recordings.
FAQs
The over-center linkage converts a user's manual movement into clamping pressure and keeps the assembly locked after the handle passes the center point. This geometry helps maintain a stable load on the lid, panel, or access port instead of relying on continuous hand force. In biomedical equipment, that arrangement supports repeatable closure during routine access and operation.
Gasket compression creates the contact needed between the closure and its sealing surface. When the toggle clamp applies compressive force, the gasket or mating surface can limit the movement of fluids, gases, and particulates through the joint. Maintaining this contact is therefore central to containment, protection of sterile conditions, and consistent device performance.
Consistent clamping force helps produce a more repeatable sealing condition each time a lid, panel, or access port is closed. That repeatability matters when equipment must contain fluids, gases, or particles, or when a sterile state must be protected. It also supports predictable operation across repeated opening and closing cycles without requiring a different manual force each time.
The closure is positioned against its gasket or sealing surface, and the toggle clamp is engaged so its linkage can apply pressure. Moving the handle through the over-center position locks the assembly and maintains compression around the joint. This sequence provides a practical way to secure housings, panels, or access ports while allowing controlled reopening when access is needed.
Applications described for this approach include equipment housings, sterilization containers, laboratory devices, and fluid-handling systems. In each case, the clamp can support a secure closure while the sealing interface helps limit leakage or protect contained conditions. Its usefulness extends across systems that require repeated access, dependable containment, or preservation of sterile conditions.
The mechanism combines secure closure with a manually operated handle, allowing an assembly to be opened and closed without replacing the entire sealing arrangement. After closure, the linkage maintains compressive force around the sealing surface. This supports repeated access while helping preserve containment, protect sterile conditions, and maintain more consistent operation of the associated device.