Flexible Protein Regions and Binding

Intrinsically disordered proteins are proteins that do not fold into one fixed three-dimensional shape. Their flexible structure helps them work with ordered proteins to do jobs that rigid proteins cannot easily do. They are found more often in eukaryotes than in prokaryotes, and they can be fully disordered or made of both ...

Proteins often have rigid secondary and tertiary structures that can be determined experimentally; however, many proteins have flexible structures without a fixed conformation.

These intrinsically disordered proteins, or IDPs, must change shape to perform their functions in an organism. 

Disordered sections of proteins contain many...