Guest Editors
Zeling Xu
South China Agricultural University
Dr. Zeling Xu is an associate professor in the Integrative Microbiology Research Center, South China Agricultural University. He obtained his undergraduate degree from Zhejiang University in China in 2014 and then received his PhD degree and Post-Doc training from the University of Hong Kong, where he studied bacterial physiology in the lab of Dr. Aixin Yan. As a researcher, his study focuses on the development of novel techniques to understand and combat bacterial antimicrobial resistance which is one of the most serious threats to global health.
Xiaolong Shao
Nanjing Agricultural University
Dr. Xiaolong Shao is an associate professor in the College of Plant Protection, Laboratory of Plant Immunity, Key Laboratory of Integrated Management of Crop Diseases and Pests, Nanjing Agricultural University. He obtained his undergraduate degree from Tianshui Normal University in China in 2013 and received his master’s degree form Northwest University. He then obtained his PhD degree from Nankai University and Post-Doc training from the City University of Hong Kong, where he studied mechanisms of bacterial pathogenicity in the lab of Dr. Xin Deng. As a researcher, his study focuses on virulence regulatory network, interaction between pathogen and host, and mRNA epigenetic modification of Pseudomonas which is one of the most international frontier research hotspots.
Huiluo Cao
The University of Hong Kong
Dr. Huiluo Cao is working in Department of Microbiology, The University of Hong Kong. He obtained his PhD degree from The University of Hong Kong in 2012 and then trained as Post-Doc in The Hong Kong University of Science and Technology. He is also the associate editor of BMC Genomics. His expertise includes bioinformatics, microbial genomics, antimicrobial resistance, and metagenomics. He has been listed on over 50 peer reviewed journal publications with over 1,500 citations and H-index 24.
Ziqing DENG
BGI-Research, BGI-Shenzhen, Shenzhen 518083, China
Dr. Ziqing DENG is an associate researcher in BGI-Research, BGI-ShenZhen. He obtained his B.S. in Environmental Science from Tongji University (Shanghai, China) in 2011, and his PhD degree in Microbiology from the University of Hong Kong (HKSAR, China) in 2017. Dr. DENG ‘s doctoral work concentrated on the molecular mechanisms of antimicrobial resistance, including multidrug efflux pump and LPS modification. His research currently focuses on high-throughput omics technologies to study antimicrobial resistance and synthetic approaches for phage engineering against MDR bacteria.
Collection Overview
A severe threat to the global health is antimicrobial resistance (AMR). Antimicrobial resistance will lead to an estimated death of around 10 million people annually due to suffering from AMR pathogens if no firm action will be taken immediately. AMR pathogens are usually equipped with complicated intrinsic, adaptive, and acquired mechanisms to survive and thrive from routine antimicrobial chemotherapies and cause life-long infections. New mechanisms are still emerging and spreading worldwide, which exacerbates the situation of unavailable drugs for future use. Understanding AMR mechanisms is urgent to reveal novel antimicrobial targets which will be important for the development of new antimicrobial drugs and precise therapeutic strategies. Moreover, discovery of broad-spectrum antimicrobial agents and establishment of alternative antimicrobial methods such as CRISPR-Cas-based bacterial killing and plasmid eradication are expected to relieve the AMR threat.
This collection aims to provide innovative methods to decipher new AMR mechanisms including high-throughput screening techniques and (meta)genomics-based predictions to identify AMR genes and regulatory pathways, efficient genome-editing tools to dissect gene functions in the genetic background of clinical AMR pathogens. This collection also provides insights into the discovery and development of novel antimicrobial agents to combat AMR, such as broad-spectrum antimicrobial peptides, CRISPR-Cas antimicrobials, phages etc. These peer-reviewed methods will greatly facilitate the fundamental research and clinical practice in dealing with the global threat of antimicrobial resistance.
Articles
Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance
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2023
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Ming Hu1, Zhengjie Liu1,2, Ziang Song1,3, Lulu Li1, Xiaonan Zhao1, Yanbo Luo1, Qing Zhang1, Yibao Chen1, Xiaohui Xu1, Yahui Dong1, Nataliia Hrabchenko1, Wei Zhang3, Yuqing Liu1
1Shandong Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, P.R. China, Key Laboratory of Livestock and Poultry Multi-omics of MARA, 2Department of Genetic and Genomes Biology, University of Leicester, 3College of Veterinary Medicine, Nanjing Agricultural University
A Stratified Genomic Framework for Salmonella Serotype Prediction: Evaluation of MLST, SeqSero, SeqSero2, SeqSero2S, and SISTR in Southwest China
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Cited by 1
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2026
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Jian Wang*1, Shihui Lu*2, Hao Lian1, Yang Yang3, Wefeng Huang4, Qiwu Yuan3, Ximei Kong3, Jiangcuo Meilang1, Yunhui Xiang5, Xiao Zhang1, Haojiang Zuo1,6,7, Ming Li3, Xiaofang Pei1,6
1West China School of Public Health and West China Fourth Hospital, Sichuan University, 2College of Pharmacy, Youjiang Medical University for Nationalities, 3Chengdu Center for Disease Control and Prevention (Chengdu Institute of Health Supervision), 4Sichuan Provincial Centre for Disease Control and Prevention, 5Department of Laboratory Medicine and Port Epidemic Disease Monitoring Key Laboratory of Sichuan Province, Sichuan International Travel and Healthcare Center (Chengdu Customs District Port Clinic), 6Health Promotion and Food Nutrition & Safety Key Laboratory of Sichuan Province, 7Innovation Center of Nursing Research and Nursing Key Laboratory of Sichuan Province, West China Hospital, Sichuan University
Abstracts
Characterization of a pathogenic Escherichia coli strain derived from fish farming activities (Oreochromis spp.) in Sinaloa, Mexico by whole-genome sequencing
Bruno Gómez-Gil1,
Francisco Delgado-Vargas2,
María Elena Báez-Flores*2,
Inés Fernando Vega-López3,
José Antonio Magaña-Lizárraga2,
José Guadalupe Rendón-Maldonado2
1Centro de Investigación y Desarrollo A.C., Unidad Mazatlán.,
2Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa.,
3Parque de Innovación Tecnológica, Universidad Autónoma de Sinaloa.
A Comprehensive Platform for Phenotypic and Genotypic AMR Analysis in Salmonella Isolates from Pork
Haojiang Zuo*1
1Sichuan University
Optimizing Metagenomic Sequencing for Antimicrobial Resistance Analysis in Meat Samples
Juan Yang1,
Haojiang Zuo*2
1Sichuan Provincial Center for Disease Control and Prevention,
2Sichuan University
Fluorescent Reporter-Based Screening Method for identification of bacterial “SOS” pathway inhibitors
Umang Gupta1,
Gokul Raj Mohan1,
Chitral Chatterjee1,
Saravanan Matheshwaran*1
1Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur