Guest Editors
Nina Filipczak
Northeastern University, Department of Pharmaceutical Sciences
Nina Filipczak is currently a postdoctoral fellow in the Department of Pharmaceutical Sciences at Northeastern University and working in the Center for Pharmaceutical Biotechnology and Nanomedicine (CPBN) laboratory headed by Dr. Vladimir Torchilin. She earned her Ph.D. from the Department of Biotechnology at the University of Wroclaw, Poland in 2017. The Ministry of Higher Education in Poland recognized her research capabilities and funded her postdoctoral study at Northeastern University. She has over seven years of graduate research experience and over 10 years of overall research experience in the drug delivery sciences. She also received her Bachelor of Science (B.S) in medical biotechnology from the University of Wroclaw. Her research focuses on using lipid and polymer drug delivery systems in the treatment of cancer at CPBN. She has published over 20 peer-reviewed papers and is experienced in the field of drug delivery and biotechnology.
Colin Cotter
Northeastern University, Department of Pharmaceutical Sciences
Colin Cotter is currently a graduate student in Pharmaceutical Sciences at Northeastern University. Colin brings a diverse range of experiences to the table. From an undergraduate background in chemistry to a lengthy career in performance tennis coaching, Colin has accumulated an extensive range of skills and abilities from his multiple careers all over the east coast. His academic work ranges from semi-organic synthesis and spectroscopy to delivery of chemotherapeutics and nucleic acids using polymeric nanocarriers. In the sports industry, he instructed athletes ranging from seniors in rehabilitation to active division 1 athletes. Outside of work, Colin enjoys studying biomechanics and most forms of exercise.
Kishan Yalamarty
Northeastern University, Department of Pharmaceutical Sciences
Kishan Yalamarty is a third-year Ph.D. student in the Department of Pharmaceutical Sciences at Northeastern University. He also serves as the outreach coordinator in the Graduate Student Association (GSA) in the department. His research interests include lipid and polymeric-based delivery systems for nucleic acid delivery in oncology indications. He has over 5 years of research experience in the field of formulation and drug delivery. Kishan also worked in liposomes and PLGA based lipid polymer hybrid nanoparticles in cancer therapy. He has authored and co-authored multiple book chapters, reviews, and research articles. Before he joined the doctoral program in Pharmaceutical Sciences, he earned an MS degree in Chemistry from Cleveland State University, Cleveland OH.
Collection Overview
Nanocarriers are powerful tools in addressing pharmaceutical and medical problems. These carriers can be utilized to solve issues ranging from toxicity, target transport, drug binding, to controlled dosing. When dealing with hydrophobic drugs, nanoparticles can alter their pharmacokinetics and target their delivery using surface ligands. By nature of the surface charge, nanocarriers can modify physicochemical functions, thus extending circulation time. In addition, drug carriers have the benefit of allowing alternative administration routes. The nanocarriers can be repurposed for nasal, ocular, and dermal deliveries, and the choice of the route of delivery can be selected based on the indication.
These carriers have spanned a broad range of approaches from synthetic polymers, natural polymers, phospholipid micelles, to metallic nanoparticles. These approaches have all been successfully used to address issues that can arise in drug delivery. New nanoparticles consisting of biodegradable polymers are also being developed and are a promising solution to the challenges posed by classical drug delivery systems.
The aim of this collection is to gather articles that can provide a source of easy-to-use and effective techniques in formulating nanoparticles and facilitate the sharing of new drug delivery systems. Overall, this collection will address the issues of safety and stability in vivo found in nano deliveries. The unique format of video articles of JoVE can assist in sharing these techniques in a much more efficient manner than traditional methods.