

Antonio Recchiuti
University of Chieti, Center for Advanced Studies and Technology, Department of Medical, Oral, and Biotechnological Science
Dr. Antonio Recchiuti is Assistant Professor in Clinical Pathology at the Department of Medical, Oral, and Biotechnological Science and at the Center for Advanced Studies and Technology, University of Chieti, Italy. Dr. Recchiuti earned his MS Degree in Pharmaceutical Chemistry and Technology and his PhD at the University of Chieti. He completed his postdoctoral training at the Brigham and Women’s Hospital – Harvard Medical school with Charles N Serhan, who discovered endogenous pro-resolving lipid mediators (SPM) resolvins, lipoxins, protectins, and maresins that are critical in the resolution of inflammation. As a postdoc, Dr. Recchiuti identified the receptors binding the endogenous SPM resolvin D1, his signaling, and modes of action in human and mouse systems (PNAS 2010, FASEB J 2011, Am J Pathol 2012). He then moved back to the University of Chieti, where he has been a Group Leader since 2014. The broad mission of his research team is to define bioactivities of SPM within the inflammatory and immune response and to promote the development of innovative therapies for the treatment of inflammation-based human pathologies, including cystic fibrosis and sickle cell disease. He has received several awards, including the ERC Marie Curie Grant, the Novartis Prize for Young Pharmacologists, and the Brigham and Women’s Hospital Spring Research Excellence Award. His research is funded by grants from the Italian Cystic Fibrosis Foundation, the American Cystic Fibrosis Foundation, the Telethon Foundation, and the Italian Ministry of Health. Link to publications: https://orcid.org/0000-0002-1409-5261

Domenico Mattoscio
University of Chieti, Center for Advanced Studies and Technology, Department of Medical, Oral, and Biotechnological Science
Domenico Mattoscio is Assistant Professor at the Department of Medical, Oral, and Biotechnological Science and at the Center for Advanced Studies and Technology, University of Chieti, Italy. Dr. Mattoscio received an MSc degree in Biology from the University of Molise, Italy, and then the PhD from the University of Chieti where he characterized the contribution of platelets to sustain chronic inflammation and failure in resolution in cystic fibrosis. He then moved to the European Institute of Oncology, Italy, where he dissected cellular pathways involved in viral-mediated tumorigenesis. After completion of his post-doctoral training, he moved back to the University of Chieti where his primary research interest is focused on the understanding of how the restoration of pro-resolution circuits is beneficial in chronic inflammatory disorders such as cystic fibrosis and cancer. The lab uses mouse models of disease coupled with multi-color flow cytometry, cell sorting, multiplex ELISA and RNA sequencing to detail the inflammatory response as a whole.
Acute inflammation is a protective host response initiated following injuries or infections. In health, this life-saving reaction, normally proceeds towards its ideal outcome, resolution, with the removal of the inciting stimulus, the counterbalance of further leukocyte infiltration, and the repair of damaged tissue. If uncontrolled or unresolved acute inflammation can contribute to the pathophysiology of many recurrent human diseases.
The COVID-19 pandemic has made starkly clear that our understanding of mechanisms that regulate acute inflammation in the human body is still incomplete and that this knowledge gap hinders the possibility of treating inflammation-based pathologies in a more efficient manner.
Contrarily to previous thoughts, it is clear now that resolution of inflammation is an active process where several cell types, endogenous chemical mediators, and biological pathways are timely and tightly regulated.
Investigations in this field now can benefit from technological advances in cell biology, omics sciences, and immunology. This methods collection aims to assemble top researchers to share unique methods to explore the resolution of inflammation and exploit it therapeutically for many human diseases.
This Methods Collection invites protocols aimed to detail the resolution of inflammation as a whole, including but not limited to:
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Cited by 3
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2023
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Roberto Plebani1,2, Alessandra D'Alessandro2, Paola Lanuti2,3, Pasquale Simeone2,3, Massimiliano Cinalli1, Ilaria Righi4, Alessandro Palleschi4,5, Matteo Mucci1,2, Marco Marchisio2,3, Francesco Cappabianca1, Marina Camera6,7, Felice Mucilli1, Mario Romano1,2
1Department of Medical, Oral and Biotechnological Sciences, “G. d’Annunzio” University of Chieti-Pescara, 2Center on Advanced Studies and Technology (CAST), “G. d’Annunzio” University of Chieti-Pescara, 3Department of Medicine and Aging Sciences, University “G. d’Annunzio” of Chieti-Pescara, 4U.O. di Chirurgia Toracica e dei Trapianti di Polmone, Fondazione IRCCS Ca’ Granda - Ospedale Maggiore Policlinico di Milano, 5Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, 6Department of Pharmaceutical Sciences, Università degli Studi di Milano, 7Unit of Cell and Molecular Biology in Cardiovascular Diseases, Centro Cardiologico Monzino IRCCS