Guest Editors
Lahari Das
Albert Einstein College of Medicine, New York City
<p>Dr. Lahari Das is a microbiologist having more than 10 years of experience in <em>Mycobacterium tuberculosis</em> research. She currently works as a postdoctoral research fellow in the laboratory of Dr. William. R. Jacobs Jr. at the Albert Einstein College of Medicine, New York City. Her research in Dr. Jacobs’ lab involves developing novel TB vaccine using herpes virus vaccine vector. She is also working on genetically engineering <em>M. leprae</em> to make a stable fluorescent reporter strain and facilitate the growth of leprosy bacilli on artificial media. These efforts when successful, would revolutionize the field of leprosy research and make leprosy vaccine studies easier.</p>
Drishya Diwaker
Albert Einstein College of Medicine, New York
<p class="ql-align-justify">Dr. Drishya Diwaker is a virologist with a background in immunology and neuroscience. She is passionate about viruses and investigates viral strategies for hijacking the host machinery, whether it is to evade the immune system or traffic down the length of neuronal axons for viral spread. She obtained her PhD degree from the Defense Institute of Physiology and Allied Sciences, India and subsequently came to the US for post-doctoral training. Currently, she is an Instructor at the Albert Einstein College of Medicine, New York. For leisure, she likes to bake and explore new places to rewire herself.</p>
Collection Overview
Tuberculosis (TB) is the major cause of morbidity and mortality in many countries. The increase in multidrug resistant (MDR) and XDR TB cases implies that more effective control measures in terms of novel drugs and vaccines need to be developed. In addition to this, Mycobacterium tuberculosis has an extremely complex biology and can modulate the host immune system to establish infection and persistence. Researchers worldwide are making tireless efforts to understand the host-pathogen interaction in TB and develop novel therapeutics to eliminate the disease.
Animal models of TB offer an easy and straight forward system to assess the disease biology and test for novel drugs and vaccines. Imaging technologies involving fluorescent and bioluminescent reporters are reliable methods to get deeper insight into ongoing host pathogen interactions and immune responses during in vivo infection in the animal models using confocal microscopy or the in-vivo imaging system (IVIS). In addition, these reporters are extremely useful in assessing the bacterial viability during drug screenings and vaccine testing. The articles published in this Method Collection will enhance our understanding of M tuberculosis biology in in vivo models. It will also aid researchers to exploit the immense potential of bioluminescent/fluorescent reporters and imaging systems to develop novel interventions for TB.
Articles
Intravital Imaging of Attenuated Auxotrophic Mycobacterium tuberculosis in Murine Lung during Early Intravascular Infection
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2026
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1Department of Pathology, Albert Einstein College of Medicine, 2Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine/Montefiore Medical Center, 3Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, 4Department of Microbiology and Immunology, Albert Einstein College of Medicine, 5Department of Genetics, Albert Einstein College of Medicine, 6Cancer Dormancy Institute, Albert Einstein College of Medicine, 7Montefiore Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine/Montefiore Medical Center
Abstracts
<p>Analyzing transcriptional profiling of THP-1 cells stably expressing Esx secretory pair of Mycobacterium tuberculosis</p>
Xilin Liu1,
Guangzhi Wu1,
Waqas Ahmad*2,
Muhammad Ahsan Naeem2
1Department of Hand Surgery, China-Japan Union Hospital, Jilin University, Changchun, Jilin, 130033, China,
2University of Veterinary and Animal Sciences, Lahore, Narowal Campus, Narowal, Pakistan