Methods for Investigating Type 2 Diabetes Remission

TOPICAL COLLECTIONS

Guest Editor

Elina Akalestou

Imperial College London

Elina Akalestou is a molecular endocrinologist specializing in bariatric surgery and inter-organ communication. Her research focuses on the effects of bariatric surgery on hypertension and Type 2 Diabetes remission. She utilizes in vivo models of bariatric surgery and transgenic and in vitro systems to explore the relationship between the gastrointestinal tract and vital metabolic organs, including adrenal glands and kidneys. Elina completed an MSc in Clinical Nutrition at University College London, followed by a PhD in Obesity Drug Development at Imperial College London. She has completed postdoctoral training at Johns Hopkins University, King's College London, and Imperial College London. She is currently a Group Leader in the Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology, and Metabolism.

Collection Overview

Type 2 Diabetes (T2D) and its serious complications contribute to poor quality of life and increase vulnerability to infections like COVID-19 and premature death. Despite significant pharmacological advances in recent years, there is still an unmet need to develop a more effective approach for tackling the pathophysiology of this disease. In order to achieve this, further research is required on the mechanisms causing diabetes, with a focus on organ communication for glucose homeostasis. This approach may include, but is not limited to, pancreatic islets, the gastrointestinal tract, liver, kidneys, brain, and adrenal glands.

Articles

8:32

Surgical Perfusion and Isolation of the Porcine Pancreas for Islet Isolation

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Cited by 1

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2024

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Sophia H. Roberts^1,2, Louai Alrata^1,2, Dahlia Abdulsattar^1,2, Karan Joseph^1,2, Wahid Abu-Amer^1,2, Mohamed Zaghloul^1,2, Batool Arif^1,2, Tarek Alhamad³, Maria S. Remedi⁴, Yiing Lin⁵, Mohamed A. Zayed^1,2,6,7

¹Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, ²CardioVascular Research Innovation in Surgery and Engineering Center, Washington University School of Medicine, ³Department of Medicine, Division of Nephrology, Washington University School of Medicine, ⁴Department of Medicine, Division of Endocrinology, Washington University School of Medicine, ⁵Department of Surgery, Section of Transplant Surgery, Washington University School of Medicine, ⁶Division of Molecular Cell Biology, Washington University School of Medicine, ⁷Department of Biomedical Engineering, Washington University McKelvey School of Engineering

6:33

Optimized Protocol for Generating Functional Pancreatic Insulin-secreting Cells from Human Pluripotent Stem Cells

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Cited by 3

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2024

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Ines Cherkaoui¹, Qian Du², Dieter Egli², Shivani Misra^1,3, Guy A. Rutter^1,4,5

¹Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Cell Biology and Functional Genomics, ²Departments of Pediatrics, Naomi Berrie Diabetes Center, Obstetrics and Gynecology, Columbia Stem Cell Initiative, Columbia University Irving Medical Center, Columbia University, ³Department of Diabetes, Imperial College Healthcare NHS Trust, ⁴Faculté de Médicine, Université de Montréal, ⁵Lee Kong Chian Imperial Medical School, Nanyang Technological University

Abstracts

Generation of insulin-secreting cells from patients with diabetes-derived induced pluripotent stem cells

Ines Cherkaoui¹,

Guy Rutter^*2,

Qian Du³,

Camille Dion⁴,

Harry Leitch ⁴,

Dieter Egli⁵,

Shivani Misra ⁶

¹Cell Biology and Functional Genomics, Imperial College London ICTEM Hammersmith Hospital,

²Section of Cell Biology and Functional Genomics, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, United Kingdom CHUM Research Center and University of Montréal, Montréal, QC, Canada Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore,

³Columbia Stem Cell Initiative (CSCI), Columbia University New York,

⁴MRC London Institute of Medical Sciences ,

⁵Columbia Stem Cell Initiative (CSCI),Columbia University New York,

⁶Diabetes & Metabolic Medicine at Imperial College Healthcare NHS

Acute Intravenous Infusion of Alpha-Melanocyte-Stimulating Hormone During an Oral Glucose Tolerance Test

Brett Johnson^*1,

Suhaniya Samarasinghe¹,

Migena Luli²,

Alex Miras³

¹Imperial College London,

²Imperial College Healthcare NHS Trust,

³Ulster University, Imperial College London