Guest Editors
Yingfei Xue
Columbia University
Dr. Xue is a postdoctoral research scientist at Columbia University Department of Surgery. He obtained his PhD degree from the University of Pittsburgh School of Pharmacy. His research interest is centered around cardiovascular implants, including bioprosthetic valves, conduits, and patches. His research goal is to better understand the mechanisms of cardiovascular implant failure and improve implant durability. He has more than 25 publications and served as an editorial board member and reviewer for multiple journals in the field of biomedical engineering.
Chiara Camillo
Columbia University
Dr. Camillo is an Associate Research Scientist at Columbia University Department of Surgery studying the molecular mechanisms that regulate endothelium and vascular morphogenesis. Her research broadly focuses on translational and clinical approaches to studying cardiovascular diseases using in vitro and in vivo models. Dr. Camillo is leading projects on thoracic aortic aneurysm development, focused on determining the impact of glycation products on cellular phenotype, extracellular matrix remodeling, and aortic wall instability.
Collection Overview
The current understanding of heart valve and aortic diseases and therapies remains largely unexplored. This is due to the unique structure and composition of heart valves and the aorta, the complex interplay between heart valve and aortic diseases, and the lack of pharmacological therapies. This Methods Collection aims to highlight the latest advancements in the field of heart valve and aortic diseases by focusing on novel methodologies developed to interrogate disease mechanisms, innovate next-generation devices and implants, and identify potential pharmaceutical therapies. Methodology studies are encouraged, including but not limited to disease modeling in vitro and in vivo, imaging techniques, heart transplant, cardiovascular device testing, cardiovascular drug delivery, and novel valve replacements.
Articles
An Ex Vivo Porcine Model for Hydrodynamic Testing of Experimental Aortic Valve Procedures and Novel Medical Devices
0 Views
•
Cited by 1
•
2023
•
V. Reed LaSala1, Halil Beqaj2, Mingze Sun1, Sabrina Castagnini3, Senay Ustunel1, Elizabeth Cordoves2, Kavya Rajesh2, Sophia Jackman2, David Kalfa1,4
1Department of Surgery, Columbia University Medical Center, 2College of Physicians and Surgeons, Columbia University, 3School of Medicine and Surgery, University of Bologna, 4Division of Cardiac, Thoracic, and Vascular Surgery, Section of Pediatric and Congenital Cardiac Surgery, New York-Presbyterian Morgan Stanley Children’s Hospital, Columbia University Medical Center
Abstracts
Two fabrication methods to assess the hydrodynamic properties and durability of customized valve models made of valve substitute materials
Mingze Sun1,
Vincent Reed LaSala1,
David Kalfa*2
1Department of Surgery, Columbia University Medical Center, New York, NY,
2Department of Surgery, Columbia University Medical Center, New York, NY; Division of Cardiac, Thoracic and Vascular Surgery, Section of Pediatric and Congenital Cardiac Surgery, New-York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY.