There is a growing interest in the cross-talk between cells via exosomes or small extracellular vesicles (sEVs). This form of intercellular communication can contribute to pathophysiological conditions where dysfunction in one organ can influence the function of other tissues. Importantly, this field extends beyond neoplastic conditions. This mode of communication occurs when a cell packages its contents into sEVs, which are then delivered to other cell types. 

Identifying the specific materials being transferred and the cell types that accept the cargo could aid in developing therapeutic strategies to mitigate these effects. Additionally, if we can find a method to capture and analyze the cargo of a particular cell type from the circulation, which contains sEVs from various cell types, it could enable the creation of early diagnostic or prognostic tests, or both, for specific diseases. This Methods Collection aims to summarize the current knowledge and outline future directions in this rapidly evolving field of research. 

For this collection, our proposal involves gathering updates on the current state of science through video demonstrations. We intend to select investigators from various focus areas to highlight the mechanism of intercellular communication among different organs throughout the body. By gathering these videos from diverse experts in the field, we can establish an "Intercellular Social Media" network to illustrate how organ-to-organ communication occurs in the human body, encompassing both normal and pathological settings.