Current Research Methods in Ex Vivo Lung Perfusion

TOPICAL COLLECTIONS

Guest Editor

Claudia Hernández-Jiménez

National Institute of Respiratory Diseases Ismael Cosío Villegas, Department of Surgery Research

Dr. Claudia Hernández Jiménez obtained her Bachelor's degree in 1996. She received her Master of Science degree in 2006 and her PhD in 2010 from the National Autonomous University of Mexico. He has conducted research in experimental surgery in animal models (mainly acute lung injury, ex vivo lung perfusion, tracheal stenosis) for more than 15 years at the National Institute of Respiratory Diseases in Mexico City. Her research focuses on the use of the ex vivo platform as a model to understand basic scientific aspects. She is currently a researcher in the Department of Experimental Surgery at the NIRD and has been awarded recognition in her country as part of the National System of Researchers, a distinction that symbolizes the quality and prestige of scientific contributions.

Collection Overview

Lung transplantation is a life-saving therapy for individuals with end-stage lung disease. Nevertheless, the demand for lung transplants surpasses the availability of donor organs. Ex vivo lung perfusion (EVLP) has emerged as a valuable tool to address this shortage. EVLP involves reconditioning the lung by simulating a physiological environment through perfusion and ventilation. To gather translational preclinical data, researchers have adopted various large and small animal models. These models include pigs, rats, and rejected human lungs. EVLP is a system that requires interdisciplinary approaches, fostering the creation of open, collaborative research networks. These networks aim to establish evidence-based pathways and gain further knowledge. Therefore, the goal of this Methods Collection is to enhance accessibility to existing methods by sharing standardized protocols for studying EVLP.