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TOPICAL COLLECTIONS

Advanced Methodologies for Venom and Toxin Research: Insights into OMICS, Molecular Pharmacology, and Translational Applications
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Guest Editor

Dr Michelle Yap

Dr Michelle Yap

Monash University Malaysia

Michelle Yap is currently a senior lecturer and course coordinator at Monash University Malaysia. She received her PhD in Molecular Medicine – specialization in toxicology and pharmacology. She is dedicated to toxin pharmacology research with background in proteomics, molecular pharmacology, immunology and biomolecular modelling of toxins. She leads Toxin Pharmacology Research Group; her research group now investigates the molecular mechanisms of venom toxins with the ultimate goal of developing next-generation biotherapeutics. Much of the group research focuses on multifaceted approaches in molecular pharmacology of venoms. Her research has also been progressively engaged in translational research, resulting in the intellectual properties produced.  

Collection Overview

Venoms are intricate cocktails of bioactive peptides and proteins with diverse pharmacological effects, positioning them as significant reservoirs for discovery and translational research. Research on venoms and toxins provides invaluable insights into molecular pharmacology, drug discovery, and the understanding of complex biological systems.  

This Methods Collection is designed to equip researchers with innovative approaches for venom and toxin research. It encompasses methodologies related to toxicology, pharmacology, omics, immunology, biochemistry, analytical chemistry, bioinformatics, and molecular biology. It includes in vitro, ex vivo, and in vivo methods, allowing for a thorough exploration of venom effects across biological systems. Interdisciplinary approaches that bridge the above-mentioned areas are also encouraged.

This collection focuses on a wide range of research topics, a few are stated below:

  • The application of omics, such as genomics, transcriptomics, proteomics, metabolomics, and lipidomics, for insights into the discovery and translational potential of venoms and toxins 
  • The use of biochemistry, toxicology, and pharmacology in functional assays to study the mechanistic actions and bioprospecting of venoms and toxins  
  • The application of bioinformatics, molecular biology (including recombinant DNA technology), immunology, and analytical chemistry for the development of therapeutics and diagnostics 

By consolidating these advanced methodologies, this Methods Collection aims to enhance the reproducibility and impact of research in the field of venoms and toxins. 

Articles

A Liposome Membrane Permeability Assay for Investigating the Effects of Phosphatidylinositol Phosphate Groups on Membranotropic Action of Venom PLA<sub>2</sub>
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A Liposome Membrane Permeability Assay for Investigating the Effects of Phosphatidylinositol Phosphate Groups on Membranotropic Action of Venom PLA2

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2025

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Abstracts

Disruptive effects of venom cytotoxin and PLA₂ on phospholipid membrane structure are abolished by phosphates of inositol ring in phosphatidylinositol

Edward Gasanoff*1

1Advanced STEM Research Center, Beijing Chaoyang KaiWen Academy, Beijing 100018, China and Belozersky Institute of Physico-Chemical Biology, M.V. Lomonosov Moscow State University, Moscow 119991, Russia

Facial Fasciculations After Rattlesnake Envenomation

Jacob Denton*1

1University of Arizona College of Medicine - Tucson