Intraductal and Local Approaches for Imaging and Functional Analyses of Breast Cancer in Mouse Models

TOPICAL COLLECTIONS

Guest Editor

Lorenzo Sempere

Michigan State University, East Lansing, MI, USA

Dr. Lorenzo Sempere is an Assistant Professor in the Department of Radiology and a Faculty member of the Campus-wide Precision Health Program at Michigan State University. Dr. Sempere is originally from Elche, a sunny city in southeastern Spain. He earned his BS in Biochemistry from Universidad Miguel Hernández and a PhD from Dartmouth Geisel School of Medicine. Dr. Sempere initiated his translational breast cancer research as a Susan G. Komen for the Cure postdoctoral fellows. Dr. Sempere has experience and expertise as author, reviewer, and journal editor in diverse areas of breast cancer research, including tissue slide-based diagnostic applications, noncoding RNA biology, functional analyses in genetically engineered mouse models, and intraductal approaches for imaging and primary prevention in animal models.

Collection Overview

Mouse models are a powerful research tool to understand the biology of breast cancer. In the last decade, there has been a surge of innovative technological and methodological approaches for modelling very specific features and aspects of breast cancer, from primary prevention to metastatic spread. This collection showcases visual methods that are unified by their common use of intraductal delivery or local manipulation to generate the breast cancer model of interest. These methods include intraductal delivery of imaging contrast agents, estrogen receptor modulators and other chemopreventive agents, and targeted agents such as siRNA for primary prevention of breast cancer studies, intraductal delivery of Cre/LoxP and/or CRISPR/Cas9 system(s) for model activation and/or functional screens, intraductal delivery or local implantation of tagged cells for lineage tracing, cellular heterogeneity, and metastatic spread studies. These methods are performed by pioneered researchers and leaders in their respective fields of basic and translational breast cancer research.