The pancreas plays a central role in metabolic regulation, digestion, endocrine signaling, and systemic homeostasis, while pancreatic disorders such as diabetes mellitus, pancreatitis, pancreatic cancer, cystic fibrosis-associated pancreatic dysfunction, and exocrine insufficiency remain major global health challenges. Rapid advances in experimental biology, bioengineering, imaging, stem cell science, genomics, and translational medicine have transformed the development of models used to investigate pancreatic physiology and disease pathogenesis.

However, the field continues to face important challenges, including limited physiological relevance of conventional in vitro systems, difficulties in reproducing complex pancreatic microenvironments, interspecies variability in animal models, restricted access to human tissues, and the need for standardized, reproducible, and clinically translatable methodologies.

This Collection aims to provide a comprehensive platform highlighting established and emerging experimental systems used to study pancreatic biology and pathology. The collection will encompass in-vitro, ex-vivo, in-vivo, computational, and clinical models, including (but not limited to) pancreatic organoids, organ-on-chip and microfluidic platforms, stem cell-derived islet and acinar models, co-culture systems, 3D bioprinting, xenograft and genetically engineered animal models, zebrafish and rodent disease models, metabolic and dietary intervention models, fibrosis and inflammation models, pancreatic cancer models, imaging-based approaches, omics-integrated platforms, AI-assisted disease modeling, patient-derived systems, surgical and transplantation models, biomarker discovery methodologies, and clinical functional assessment techniques.

The goal of this collection is to consolidate reproducible protocols, methodological innovations, and translational strategies that improve the study of pancreatic function and disease progression. By bringing together diverse methodologies across basic, preclinical, and clinical research, this collection will serve as a valuable resource for researchers, clinicians, bioengineers, and translational scientists, facilitating standardization, interdisciplinary collaboration, and the accelerated development of diagnostic and therapeutic advances in pancreatic research.