Guest Editors
Hongyu Zhang
Chinese Academy of Medical Sciences; Peking Union Medical College
Hongyu Zhang conducts research at Peking Union Medical College, focusing on clinical and translational studies in surgery and tissue regeneration, as well as the intersection of neuroscience and intelligent medicine. His work also includes the application of multi-omics and artificial intelligence in neurological conditions and organ repair. Additionally, he serves as a Young Editorial Board Member for iMeta and is a peer reviewer for over 10 journals, primarily focusing on medicine, big data, AI, and clinical translational research.
Dingkang Xu
Department of Neurosurgery, Guangdong Provincial People's Hospital
Dr. Dingkang Xu is an attending physician in the Department of Neurosurgery at Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences). He received his PhD from Peking Union Medical College.He has published over 30 peer-reviewed SCI-indexed papers, with an h-index of 12. Dr. Xu has led a Youth Program of the National Natural Science Foundation of China and participated in several major projects, including the National Key R&D Program of China, the General Program of the Guangdong Basic and Applied Basic Research Foundation, and the General Program of the Shenzhen Science and Technology Innovation Commission.His research focuses on big data, multi-omics, and real-world studies of cerebrovascular diseases and brain tumors, as well as the molecular regulation of the blood-brain barrier.
Xinzhan Jiang
Harbin Medical University
Dr. Xinzhan Jiang is a researcher at Harbin Medical University. Her research interests encompass neuroimmunology, autoimmune diseases, and oncology, with a particular focus on the immunological mechanisms underlying disease pathogenesis, novel therapeutic strategies, and the application of artificial intelligence and multi-omics big data analytics to biomedical research. She participated in multiple projects funded by the National Natural Science Foundation of China. She also serves on the editorial boards of multiple international journals and as an invited peer reviewer, contributing to the advancement of research in immunology, neuroscience, and interdisciplinary biomedical sciences.
Chaoqun You
Department of Bone Tumor, Peking University People’s Hospital
Chaoqun You conducts research in the Department of Bone Tumor at Peking University People’s Hospital (Beijing, China), focusing on innovative strategies for bone tumor treatment. His work emphasizes 3D printing, hydrogel-based biomaterials, personalized therapy, and translational clinical applications. His current work is dedicated to integrating biomaterials, precision medicine, and clinical needs to develop more effective and individualized therapeutic approaches, with the aim of promoting the clinical translation of novel technologies in musculoskeletal oncology.
Collection Overview
The exponential growth of medical big data presents both unprecedented opportunities and significant challenges for modern clinical research. Bridging complex disease mechanisms and translating laboratory discoveries into clinical practice increasingly relies on the integration of artificial intelligence (AI), bioinformatics, and advanced analytical methodologies, including Mendelian Randomization and bibliometric analysis. These data-driven approaches enable researchers to move beyond wet-lab paradigms, offering powerful tools to predict clinical trajectories, identify causal relationships, and uncover novel therapeutic targets with greater precision.
This collection aims to showcase practical applications and methodological innovations in leveraging AI, bioinformatics, and advanced analytics for clinical research. By emphasizing robust computational frameworks and intelligent medicine strategies, it provides guidance for navigating complex, multidimensional datasets, thereby accelerating biomedical discovery and advancing the realization of precision medicine.
Articles
Abstracts
Hemoglobin Glycation Index (HGI) as a Novel Predictor of Mortality in Critically Ill Non-Diabetic Sepsis Patients
Yaohua Yu1,
Jiaqi Lou1,
Xin Le*1
1Burn Department, Ningbo No. 2 Hospital, Wenzhou Medical University
Global bibliometric and visualized analysis of natural products against glioma from 2012 to 2025
Haixiang Feng1,
Shikai Wang1,
Fangchun Xu1,
Bao Bingzhangke1,
Liangwang Yang1,
Taixue Chen1,
Shenbo Chen*1,
Jigao Feng*1,
Shenghua Zhuo*1
1Hainan Medical University
Predicting lateral lymph node metastasis in papillary thyroid carcinoma based on ultrasound radiomics of the intratumoral and pertitumoral regions
Min Wei*1
1Cancer Center, Department of Ultrasound Medicine, Zhejiang Provincial People's Hospital ( Affiliated People's Hospital ), Hangzhou Medical College
Exogenous Insulin Exposure Increases Osteoarthritis Risk: A Mendelian Randomization Study with In-Vitro Validation
rong lingbo1
1wuhan university
Causal inference of immune cells characteristics and circulating metabolites on intervertebral disc infection and discitis risk
Hu Xuexin1
1KunmingUniversityofScienceandTechnology
Bibliometric and visual analysis of synthetic lethality for glioma from 2012 to 2025
Shikai Wang1,
Bao Bingzhangke1,
Haixiang Feng1,
Chuan Lin1,
Yang Zhang1,
Guanghai Cao1,
Fangchun Xu1,
Boyu Chen1,
Taixue Chen*1,
Jigao Feng*1,
Shenghua Zhuo*1
1Hainan Medical University
Construction and Internal Validation of a Machine Learning Model for Predicting 30-Day Readmission After Hip Surgery
Cuicui Dou*1
1Department of Anesthesiology, Guangxi Zhuang Autonomous Region People's Hospital, Nanning, Guangxi, China
Global Trends in Gut Microbiota and Metabolic Syndrome Research: A Bibliometric and Visualized Analysis
Ming Xu1,
Chunhui Wang2,
Yongkang Wu3,
Qi Yu*1
1Integrated Chinese and Western Medicine Colorectal Departmentr, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, Shandong, China,
2Chinese Center for Disease Control and Prevention, Qingdao 266000, Shibei District, China. ,
3Health Bureau of Laoshan District, Qingdao 266100，Laoshan District，China.
Content and Quality Analysis of Online Information on Chikungunya fever in the Digital Media Era: A Cross-Sectional Study
Jialin Lu1,
Yiran Gao1,
Min Wei1,
Yanping Wang1,
Peng Wang1,
Nan Meng1,
Huan Liu1,
Kexin Wang*1,
Qunhong Wu*1
1Department of Social Medicine, Health Management College, Harbin Medical University, Harbin, 150081 China
The Progress and Prospect of Microglia and Macrophage Research in Intracerebral Hemorrhage: A Bibliographic Analysis
Xin Hu*1
1Department of Neurosurgery, West China Hospital, Sichuan University.
Construction of a Prognostic Model Based on R-loop Related Genes and Analysis of Immune Characteristics in Colon Adenocarcinoma
Lijuan Wei1
1Hohhot First Hospital， Hohhot, Inner Mongolia
The LY6D Gene Promotes the Progression of Non-Small Cell Lung Cancer by Regulating the EGFR-FOXM1 Signaling Axis
Qi Sun1
1Harbin Medical University