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Developmental Toxicity of Environmental Chemicals: Current Approaches and Models

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Guest Editors

Tao Chen

Tao Chen

Soochow University, Department of Toxicology

Dr. Tao Chen is a Professor in the Department of Toxicology at SooChow University, SuZhou, China. His lab focuses on the cardiac developmental toxicity of environmental chemicals. In recent years, his team has revealed the important role of AHR in PM2.5 and Trichloroethylene- induced heart defects during early embryo development. He is also interested in epigenetic mechanisms of carcinogenicity of environmental chemicals. Dr Chen received his PhD degree from institute of Zoology, Chinese Academy of Sciences in 2005. Prior to joining in Soochow University, he carried out post-doctoral researches at the University of Birmingham on furan toxicity, and at University of Newcastle on DNA damage/repair. He has published over 40 peer-reviewed papers and is a co-inventor on several patent applications.

Stanley Aniagu

Stanley Aniagu

Texas Commission on Environmental Quality; Toxicology, Risk Assessment, & Research Division

Dr. Aniagu works as a toxicologist in the Texas Commission on Environmental Quality's Toxicology, Risk Assessment, and Research Division. Dr. Aniagu helps with the derivation of toxicity such as effects screening levels (ESLs), in addition to conducting the of air permit applications in accordance with agency guidance and protocols. He also helps to conduct advanced toxicological evaluations and risk assessments to determine potential health risks associated with exposure to environmental contaminants, including health effects reviews of ambient air monitoring data. A major part of his work also involves reviewing and coordinating risk assessments for criteria air pollutants (i.e. NAAQS). Dr. Aniagu has 21 years of combined experience in mechanistic and regulatory toxicology, healthcare research, and practice. Dr. Stanley Aniagu holds a Bachelor of Pharmacy degree from the Obafemi Awolowo University, Ile-Ife, Nigeria. He also obtained a Master of Science degree in Toxicology as well as a PhD in Environmental & Molecular Toxicology from the University of Birmingham, England. With a book chapter and over 20 peer-reviewed articles in international journals, Dr. Aniagu is always seeking for research and development opportunities, especially in the areas of mechanistic toxicology, carcinogenesis, and risk assessment of environmental chemicals.

Yan Jiang

Yan Jiang

Soochow University, Department of Physiology

Dr. Yan Jiang is an Associate Professor in the Department of Physiology at Soochow University, Suzhou, China. She obtained her PhD from the Institute of Zoology, Chinese Academy of Sciences in 2006. She then worked as a post-doctoral research fellow at Warwick University and Newcastle University to study stem cell differentiation. Dr. Jiang’s lab is mainly focused on the molecular mechanisms of environmental pollution-induced congenital heart diseases using embryonic stem cell cardiac differentiation and zebrafish embryo early developmental models. Dr Jiang has published over 30 peer-reviewed articles in international journals, as well as one book chapter.

Collection Overview

The embryo/fetus is highly susceptible to environmental toxicants. Maternal exposure to environmental pollutions can result in congenital malformations and spontaneous abortion. This is especially true for environmental chemicals such as ethanol, PAHs, and PCBs, which can cross the placental barrier and bioaccumulate in the embryo/fetus. Thus, understanding the mechanisms through which environmental chemicals cause developmental toxicities would be of great benefit in the prevention or treatment of chemical-induced spontaneous abortion or congenital diseases. Unfortunately, traditional animal models are either too laborious or insensitive to developmental toxic effects. New methods based on the differentiation of stem cells or other animal models such as zebrafish and chicken embryos have emerged. Overall, this methods collection aims to provide details to researchers about novel animal and cell culture models for studying the developmental toxicities of environmental chemicals. 

Editorial

Current Techniques and Models for Assessing the Developmental Toxicity of Environmental Pollutants

Current Techniques and Models for Assessing the Developmental Toxicity of Environmental Pollutants

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2023

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Tao Chen*1

1soochow university