Guest Editors
Anne-Sophie Wattiez
University of Iowa and Iowa City VA Medical Center
Dr. Anne-Sophie Wattiez is a research scientist at the University of Iowa and Iowa City VA Medical Center, working primarily with animal models of post-traumatic headache and migraine. The primary focus of her research is the study of chronic pain and its associated symptoms. It has always been important to her to work in a field close to medicine, where she could envision the benefits of her research in patients. This is also the reason why she is very interested in migraine/headache and pain manifestations in terms of translatable behaviors, including hypersensitivity as well as emotional and cognitive perturbations. Studying migraine and headache is very challenging, but it makes it that much more exciting when the results of fundamental research are extended into clinical trials. The hope of alleviating human suffering is her greatest motivation for working rigorously.
Sarah Louise T. Christensen
Rigshospitalet Glostrup, Danish Headache Center, Department of Neurology
Dr. Sarah Louise T. Christensen is a senior scientist in the preclinical research group of the Danish Headache Center working primarily with animal models of migraine. She originally trained as a veterinarian with a specialization in biomedical research and obtained her PhD in Health and Medical Science from the University of Copenhagen in 2018 based on the thesis ‘Development of a behavioral animal model of migraine.’ Working in a translational environment, her current research focuses on dissecting signaling pathways involved in the generation of migraine pain.
Collection Overview
Collectively migraine and other headache disorders (including tension-type headache, medication overuse headache, post-traumatic headache to name a few) are leading causes of disability worldwide. While different headache disorders have distinct clinical characteristics, they also share many commonalities both in terms of symptomatology, molecular targets, mechanisms, and treatments. Headache disorders are often complex and not fully understood in terms of pathophysiological mechanisms which include interactions between neuronal, immune, and vascular systems. Thus, pre-clinical research using animal -and other model systems- is necessary but difficult, and no methods are considered golden standards. Reproducibility between different laboratories is a key to progress, yet methods vary from one study to the other, making it difficult to compare results.
With this Methods Collection, we aim to gather current and essential methods to study headache disorders in preclinical models. Techniques will include in vivo, ex vivo, and in vitro assays. Papers should focus on providing a clear and transparent protocol and thoroughly discuss the strengths and possible pitfalls of the method, including its translational value.
Articles
Investigating Migraine-Like Behavior Using Light Aversion in Mice
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Cited by 19
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2021
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Mengya Wang1, Bianca N. Mason2, Levi P. Sowers3,4, Adisa Kuburas4, Brandon J. Rea3,4, Andrew F. Russo3,4,5
1Department of Neuroscience and Pharmacology, University of Iowa, 2School of Behavioral and Brain Sciences, University of Texas at Dallas, 3Center for the Prevention and Treatment of Visual Loss, Veterans Administration Health Center, Iowa City, IA, 4Department of Molecular Physiology and Biophysics, University of Iowa, 5Department of Neurology, University of Iowa
Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents
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Cited by 4
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2022
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Abstracts
Closed and unfixed skull weight drop as a mice model of mild traumatic brain injury (mTBI) for post-traumatic headache studies
Frank Porreca*1,
Trent Anderson2,
Edita Navratilova*1,
Caroline Kopruszinski3
1Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona, USA and Department of Neurology, Mayo Clinic, Phoenix, USA,
2Department of Basic Medical Sciences, College of Medicine, University of Arizona, Phoenix, Arizona, USA,
3Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona, USA
Development of automated facial pain detection in a mouse model of migraine
Brandon Rea*1,
Levi Sowers2,
Andrew Russo3,
Randy Kardon4,
Pieter Poolman4,
Aaron Fairbanks1,
Abigail Davison1,
Anne-Sophie Wattiez*5
1Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, IA, United States,
2Center for the Prevention and Treatment of Visual Loss, Iowa VA Medical Center, Iowa City, IA, United States; Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, IA, United Statesv,
3Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, IA, United States; Center for the Prevention and Treatment of Visual Loss, Iowa VA Medical Center, Iowa City, IA, United States; Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA, United States,
4Center for the Prevention and Treatment of Visual Loss, Iowa VA Medical Center, Iowa City, IA, United States; Department of Ophthalmology and Visual Sciences,
5Center for the Prevention and Treatment of Visual Loss, Iowa VA Medical Center, Iowa City, IA, United States; Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, IA, United States