Multiple Repetitions

Multiple repetitions are the repeated presentation of a behavior, task, or stimulus across trials to measure response consistency and change over time. In behavioral research, researchers keep relevant conditions as consistent as possible while recording each response, allowing random variation to be distinguished from systematic effects such as learning, habituation, fatigue, or reinforcement. Repeated trials can improve measurement reliability, reveal individual differences, and clarify how behavior changes with experience. This approach supports studies of conditioning, decision-making, motor performance, and social behavior, while careful control of trial order and rest periods helps reduce practice and carryover effects.

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JoVE Core - Pharmacokinetics and Pharmacodynamics

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

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2025

Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...

Research

JoVE Journal - Medicine

A Repetitive Concussive Head Injury Model in Mice

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Cited by 5 •

2016

Concussion presents the most common type of traumatic brain injury. Therefore, a repetitive concussive animal model, which replicates the important features of an injury in patients, may provide a means to study concussion in a rigorous, controlled, and efficient manner.

Novel Object Exploration as a Potential Assay for Higher Order Repetitive Behaviors in Mice

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Cited by 10 •

2016

Higher order restricted, repetitive behaviors (RRBs) disrupt the lives of affected individuals. These behaviors are challenging to model in rodents, making basic biomedical research into potential treatments or interventions for RRBs difficult. Here we describe novel object exploration as a potential assay for higher order RRBs in mice.

Neuronal Adaptation to Repetitive Hypoxic Preconditioning in Mice

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2025

Source: Poinsatte, K., et al., Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice. J. Vis. Exp. (2015)This video demonstrates the method of repetitive hypoxic preconditioning (RHP) by exposing a mouse to controlled hypoxia cycles before inducing an ischemic stroke. The experiment evaluates its effects on blood-brain barrier stability, neuronal adaptation, and inflammation.

Research

JoVE Journal - Medicine
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The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool

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Cited by 106 •

2014

Precise measurement of neurological and neuropsychological impairment and disability in multiple sclerosis is challenging. We report methodologic details on a new test, the Multiple Sclerosis Performance Test (MSPT). This new approach to the objective of quantification of MS related disability provides a computer-based platform for precise, valid measurement of MS severity.

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