Neurological Integrity Testing

Neurological integrity testing is the systematic assessment of whether the nervous system is functioning normally, linking neural activity to observable behavior and performance. It uses standardized observations and tasks to evaluate responses such as sensation, movement, reflexes, coordination, attention, and other behavioral indicators, helping identify disruptions in specific neural pathways. In behavioral science and neuroscience, these assessments provide objective measures of brain and spinal cord function, support the characterization of neurological disorders or injury, and help track changes over time. Results can also guide research on how neural systems regulate behavior and evaluate the effects of interventions.

Neurological Integrity Testing - Related Videos

Research

JoVE Journal - Neuroscience

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis

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Cited by 21 •

2016

An optimized testing protocol is presented in this paper for the Rotarod performance test, used for measuring progressive neurological disability in TMEV-infected mice.

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS

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Cited by 120 •

2015

This video protocol describes a sensitive, reliable, and quick method for evaluating the neuromuscular deficits in a transgenic mouse model of amyotrophic lateral sclerosis.

Lipidomics and Transcriptomics in Neurological Diseases

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Cited by 13 •

2022

This article presents a modular protocol for tissue lipidomics and transcriptomics, and plasma lipidomics in neurological disease mouse models targeting lipids underlying inflammation and neuronal activity, membrane lipids, downstream messengers, and mRNA-encoding enzymes/receptors underlying lipid function. Sampling, sample processing, extraction, and quantification procedures are outlined.

Education

JoVE Science Education - Psychology

Balance and Coordination Testing

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2023

Balance and coordination are critical components involved in the control of movement. Many sensory receptors and neural processing units are required to help individuals maintain balance while performing various activities. Deficits in balance and coordination occur in patients suffering from movement disorders or due to aging. Therefore, scientists are trying to understand the pathophysiology behind these conditions. One way to do that is by using rodent models and testing them on behavioral...

Research

JoVE Journal - Medicine
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Quantitative Autonomic Testing

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Cited by 179 •

2011

Standardized, comprehensive and fully quantitative testing of autonomic functions is described. The autonomic tests consist of evaluation of all three major autonomic domains including cardiovagal, adrenergic and sudomotor. The severity and distribution of dysautonomia is quantitated using Composite Autonomic Severity Scores.

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