Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis

Journal

Neuroscience

JoVE Journal
Neuroscience

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JoVE Journal Neuroscience

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis

DOI:

10.3791/54616-v

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08:11 min

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November 14, 2016

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Francesca Gilli, Darlene B. Royce, Andrew R. Pachner

¹Department of Neurology,Geisel School of Medicine at Dartmouth

Chapters

00:05Title
01:14Rotarod Training
03:08Mouse TMEV Infection
04:37Rotarod Experiment
06:12Results: Rotarod Performance Test Shows Lower NFI Values in TMEV-infected MIce Compared to Sham-controls
07:02Conclusion

Summary

Automatic Translation

An optimized testing protocol is presented in this paper for the Rotarod performance test, used for measuring progressive neurological disability in TMEV-infected mice.

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis

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